Sox1 - SRY (sex determining region Y)-box 1 Gene

Also Known as Sox-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20664

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in interneuron migration; regulation of oligodendrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor; generation of neurons; and lens morphogenesis in camera-type eye. Located in nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; large intestine; and neural ectoderm. Orthologous to human SOX1 (SRY-box transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sox1 Products (1)

mRNA	Protein	Name
NM_009233.3	NP_033259.2	transcription factor SOX-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8625802	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9512512	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9512512	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15110721	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9512512	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to leukemia inhibitory factor	IDA IDA: Inferred from direct assay	20439489	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15882093	MGI
acts upstream of or within forebrain neuron development	IMP IMP: Inferred from mutant phenotype	15882093	MGI
acts upstream of or within forebrain neuron differentiation	IMP IMP: Inferred from mutant phenotype	15882093	MGI
involved in interneuron migration	IMP IMP: Inferred from mutant phenotype	20844123	MGI
acts upstream of or within lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	9512512	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15110721	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	15882093	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9512512	MGI
involved in regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19723505	MGI
acts upstream of or within ventral spinal cord interneuron specification	IMP IMP: Inferred from mutant phenotype	20844123	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9512512	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor SOX-1	SRY-box containing gene 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12273	DMH-1	Inhibitor	99.95%	Unkown
HY-133028	CKI-7 free base	Inhibitor	99.31%	Unkown
HY-W011109	CKI-7	Inhibitor	99.97%	Unkown
HY-RS13582	SOX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-12273G	DMH-1 (GMP)	Inhibitor	/	Unkown
HY-RS19383	Sox1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25875	Sox1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox1	NCBI	NCBI:6656