Sox3 - SRY (sex determining region Y)-box 3 Gene

Also Known as Sox-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20675

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including diencephalon development; face development; and sex determination. Acts upstream of or within animal organ development and spermatid differentiation. Predicted to be located in nucleoplasm. Is expressed in several structures, including brain; branchial arch; early conceptus; embryo ectoderm; and gonad. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in X-linked panhypopituitarism. Orthologous to human SOX3 (SRY-box transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Sox3 Products (1)

mRNA Protein Name
NM_009237.3 NP_033263.2 transcription factor SOX-3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
8625802 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11875113 MGI
Biological Process GO Annotation Evidence References Source
involved in Sertoli cell development IEP
IEP: Inferred from expression pattern
11875113 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
14981518 MGI
involved in face development IMP
IMP: Inferred from mutant phenotype
17728342 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
14981518 MGI
involved in hypothalamus development IMP
IMP: Inferred from mutant phenotype
14981518 MGI
involved in pituitary gland development IMP
IMP: Inferred from mutant phenotype
14981518 MGI
involved in sensory organ development IMP
IMP: Inferred from mutant phenotype
17728342 MGI
involved in sex determination IMP
IMP: Inferred from mutant phenotype
21183788 MGI
acts upstream of or within spermatid differentiation IMP
IMP: Inferred from mutant phenotype
15893302 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor SOX-3

  • SRY-box containing gene 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13593 SOX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22330 Sox3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28852 Sox3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sox3 NCBI NCBI:6658