Aurkc - aurora kinase C Gene

Also Known as AIE1; AIK3; IAK3; ARK-3; Stk13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20871

About Aurkc

Chromosome 7: 6,998,299-7,006,090 forward strand.GRCm39:CM001000.3

This gene has 5 transcripts (splice variants), 99 orthologues, 2 paralogues and is associated with 5 phenotypes. Biased expression in testis adult (RPKM 2.8), ovary adult (RPKM .2) and 1 other tissue.

Summary

Enables protein kinase activity. Acts upstream of or within protein autophosphorylation. Located in chromosome, centromeric region and meiotic spindle midzone. Is expressed in gonad. Human ortholog(s) of this gene implicated in spermatogenic failure 5. Orthologous to human AURKC (Aurora Kinase C). [provided by Alliance of Genome Resources, Apr 2022]

Aurkc Products (3)

mRNA Protein Name
NM_020572.2 NP_065597.2 aurora kinase C isoform b
NM_001080966.1 NP_001074435.1 aurora kinase C isoform b
NM_001080965.1 NP_001074434.1 aurora kinase C isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein kinase activity IDA
IDA: Inferred from direct assay
9809744 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
9809744 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
21558374 MGI
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
12584241 MGI
located in meiotic spindle midzone IDA
IDA: Inferred from direct assay
21558374 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aurkc Protein Structure

PKc_like

PKc_like: cl21453 (8 - 274)

  • 0
  • 100
  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

aurora kinase C

  • aurora 3

  • aurora B

  • aurora-related kinase 3

  • aurora/IPL1-related kinase 3

  • aurora/Ipl1/Eg2 protein 1

  • serine/threonine kinase 13 (aurora/IPL-like)

  • serine/threonine-protein kinase 13

  • serine/threonine-protein kinase aurora-C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175525 MS44 Degrader 99.81% Unkown
HY-120279A CFI-400437 Inhibitor / Unkown
HY-123610 BRD-7880 Inhibitor / Unkown
HY-160691 GW814408X Inhibitor / Unkown
HY-RS01273 AURKC Human Pre-designed siRNA Set A / Unkown
HY-RS01274 Aurkc Mouse Pre-designed siRNA Set A / Unkown
HY-RS01275 AURKC Rat Pre-designed siRNA Set A / Unkown
HY-119948 AKCI Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aurkc NCBI NCBI:6795