Sirt7 - sirtuin 7 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 209011

About Sirt7

Chromosome 11: 120,509,198-120,516,066 reverse strand.GRCm39:CM001004.3

This gene has 11 transcripts (splice variants), 189 orthologues, 6 paralogues and is associated with 33 phenotypes. Ubiquitous expression in spleen adult (RPKM 45.7), thymus adult (RPKM 44.) and 28 other tissues.

Summary

Enables NAD-dependent histone deacetylase activity (H3-K18 specific) and protein-propionyllysine depropionylase activity. Involved in several processes, including homologous chromosome pairing at meiosis; protein deacylation; and regulation of double-strand break repair via nonhomologous end joining. Located in chromatin and site of double-strand break. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; eye; gonad; and spleen. Orthologous to human SIRT7 (Sirtuin 7). [provided by Alliance of Genome Resources, Apr 2022]

Sirt7 Products (2)

mRNA	Protein	Name
NM_153056.3	NP_694696.2	NAD-dependent protein deacetylase sirtuin-7 isoform 1
NM_001363439.1	NP_001350368.1	NAD-dependent protein deacetylase sirtuin-7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD-dependent histone H3K18 deacetylase activity	IMP IMP: Inferred from mutant phenotype	27225932	MGI
enables NAD-dependent protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	25200183	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25200183	MGI
enables protein-propionyllysine depropionylase activity	IDA IDA: Inferred from direct assay	30026585	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in DNA repair-dependent chromatin remodeling	IMP IMP: Inferred from mutant phenotype	27225932	MGI
involved in homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	31256246	MGI
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	31226208	MGI
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	30026585	MGI
involved in protein deacetylation	IDA IDA: Inferred from direct assay	25200183	MGI
involved in protein depropionylation	IDA IDA: Inferred from direct assay	30026585	MGI
involved in regulation of mitochondrion organization	IMP IMP: Inferred from mutant phenotype	25200183	MGI
involved in regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	31075303	MGI
involved in retrotransposon silencing	IMP IMP: Inferred from mutant phenotype	31226208	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	31226208	MGI
located in site of double-strand break	IMP IMP: Inferred from mutant phenotype	27225932	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt7 Protein Structure

Smc

SIRT7

0
100
200
300
402 a.a.

Protein Preferred Names	Protein Names
NAD-dependent protein deacetylase sirtuin-7	NAD-dependent deacetylase sirtuin-7 NAD-dependent protein deacylase sirtuin-7 SIR2-like protein 7 regulatory protein SIR2 homolog 7

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135899	SIRT7 inhibitor 97491	Inhibitor	98.81%	Unkown
HY-159124	YZL-51N	Inhibitor	95.0%	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	98.37%	Unkown
HY-156489	Epigenetic factor-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sirt7	NCBI	NCBI:51547