Lpcat1 - lysophosphatidylcholine acyltransferase 1 Gene

Also Known as rd11; Aytl2; LPCAT; LPCAT-1; mLPCAT1; lysoPAFAT; 2900035H07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 210992

Summary

Enables O-acyltransferase activity. Involved in phospholipid biosynthetic process. Acts upstream of or within several processes, including negative regulation of phosphatidylcholine biosynthetic process; positive regulation of protein catabolic process; and surfactant homeostasis. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including eye; genitourinary system; lung; nervous system; and vascular system. Orthologous to human LPCAT1 (lysophosphatidylcholine Acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Lpcat1 Products (3)

mRNA Protein Name
NM_001368681.1 NP_001355610.1 lysophosphatidylcholine acyltransferase 1 isoform 2
NM_001368682.1 NP_001355611.1 lysophosphatidylcholine acyltransferase 1 isoform 3
NM_145376.6 NP_663351.3 lysophosphatidylcholine acyltransferase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: Inferred from direct assay
16704971 MGI
enables 1-alkylglycerophosphocholine O-acetyltransferase activity IDA
IDA: Inferred from direct assay
18285344 MGI
enables 1-alkylglycerophosphocholine O-acyltransferase activity IDA
IDA: Inferred from direct assay
16704971 MGI
enables plasmalogen synthase activity IDA
IDA: Inferred from direct assay
16704971 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of phosphatidylcholine biosynthetic process IDA
IDA: Inferred from direct assay
20018880 MGI
acts upstream of phosphatidylcholine biosynthetic process IDA
IDA: Inferred from direct assay
20018880 MGI
involved in phospholipid biosynthetic process IDA
IDA: Inferred from direct assay
16704971 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
20018880 MGI
acts upstream of protein catabolic process IDA
IDA: Inferred from direct assay
20018880 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within surfactant homeostasis IDA
IDA: Inferred from direct assay
20018880 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16704971 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16704971 MGI
located in membrane IDA
IDA: Inferred from direct assay
18156367 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysophosphatidylcholine acyltransferase 1

  • 1-acylglycerol-3-phosphate O-acyltransferase

  • 1-acylglycerophosphocholine O-acyltransferase

  • 1-alkenylglycerophosphocholine O-acyltransferase

  • 1-alkylglycerophosphocholine O-acetyltransferase

  • LPC acyltransferase 1

  • acetyl-CoA:lyso-PAF acetyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W140439 1-Oleoyl-sn-glycero-3-phosphocholine 99.58% Unkown
HY-112825 TSI-01 Inhibitor 98.52% Unkown
HY-RS07764 LPCAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18199 Lpcat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24675 Lpcat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpcat1 NCBI NCBI:79888