Slc18a2 - solute carrier family 18 (vesicular monoamine), member 2 Gene

Also Known as Vmat2; 9330105E13; 1110037L13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214084

Summary

Predicted to enable several functions, including amine transmembrane transporter activity; heat shock protein binding activity; and serotonin:sodium symporter activity. Involved in neurotransmitter loading into synaptic vesicle. Acts upstream of or within several processes, including locomotory behavior; response to amphetamine; and response to toxic substance. Located in dopaminergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; eye; integumental system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease and type 1 diabetes mellitus. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Apr 2022]

Slc18a2 Products (1)

mRNA Protein Name
NM_172523.3 NP_766111.1 synaptic vesicular amine transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19357284 MGI
Biological Process GO Annotation Evidence References Source
involved in histamine secretion by mast cell IMP
IMP: Inferred from mutant phenotype
10618388 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
9275230 MGI
involved in neurotransmitter loading into synaptic vesicle IDA
IDA: Inferred from direct assay
9427251 MGI
involved in neurotransmitter loading into synaptic vesicle IMP
IMP: Inferred from mutant phenotype
9427251 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
9275230 MGI
acts upstream of or within response to amphetamine IMP
IMP: Inferred from mutant phenotype
9275230 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
9275230 MGI
involved in serotonin secretion by mast cell IMP
IMP: Inferred from mutant phenotype
10618388 MGI
Cellular Component GO Annotation Evidence References Source
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
9427251 MGI
is active in dopaminergic synapse IMP
IMP: Inferred from mutant phenotype
9427251 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
9427251 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptic vesicular amine transporter

  • VAT2

  • monoamine transporter

  • solute carrier family 18 member 2

  • vesicular amine transporter 2

  • vesicular monoamine transporter 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13044 SLC18A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22032 Slc18a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28550 Slc18a2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc18a2 NCBI NCBI:6571