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Tcf21 - transcription factor 21 Gene

Also Known as epc; Pod1; Pod-1; bHLHa23; capsulin; epicardin

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21412

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and Androgen Receptor binding activity. Involved in several processes, including animal organ development; negative regulation of Androgen Receptor signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including lung development; nephron development; and sex determination. Predicted to be located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart and pericardium; and respiratory system. Orthologous to human TCF21 (transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]

Tcf21 Products (1)

mRNA	Protein	Name
NM_011545.2	NP_035675.1	transcription factor 21

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9545526	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11287187	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	15919722	MGI
enables E-box binding	IPI IPI: Inferred from physical interaction	9545521	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	9545521	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	15919722	MGI
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	15919722	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11591653	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10944221	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	9507058	MGI
involved in branchiomeric skeletal muscle development	IGI IGI: Inferred from genetic interaction	12493912	MGI
acts upstream of or within bronchiole development	IMP IMP: Inferred from mutant phenotype	10572052	MGI
involved in diaphragm development	IGI IGI: Inferred from genetic interaction	12493912	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	10572052	MGI
acts upstream of or within glomerulus development	IMP IMP: Inferred from mutant phenotype	10572052	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	10572052	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	10572052	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	10572052	MGI
acts upstream of or within lung vasculature development	IMP IMP: Inferred from mutant phenotype	10572052	MGI
involved in metanephric glomerular capillary formation	IMP IMP: Inferred from mutant phenotype	12619136	MGI
involved in metanephric mesenchymal cell differentiation	IMP IMP: Inferred from mutant phenotype	12619136	MGI
acts upstream of or within morphogenesis of a branching structure	IMP IMP: Inferred from mutant phenotype	10572052	MGI
involved in negative regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	15919722	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11287187	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9545526	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	10572052	MGI
acts upstream of or within respiratory system development	IMP IMP: Inferred from mutant phenotype	10572052	MGI
involved in roof of mouth development	IGI IGI: Inferred from genetic interaction	12493912	MGI
acts upstream of or within sex determination	IMP IMP: Inferred from mutant phenotype	10572052	MGI
acts upstream of or within sex differentiation	IMP IMP: Inferred from mutant phenotype	15289436	MGI
involved in spleen development	IMP IMP: Inferred from mutant phenotype	10944221	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	10572052	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	10572052	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9545521	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor 21	podocyte-expressed 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14303	TCF21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21064	Tcf21 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27581	Tcf21 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tcf21	NCBI	NCBI:6943