Kmt2a - lysine (K)-specific methyltransferase 2A Gene

Also Known as HRX; Mll; All1; Mll1; ALL-1; Cxxc7; HTRX1; mKIAA4050; 6430520K01

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214162

Summary

Enables DNA binding activity; chromatin binding activity; and Histone Methyltransferase activity (H3-K4 specific). Involved in several processes, including definitive hemopoiesis; regulation of gene expression; and regulation of histone modification. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; hematopoietic system; nervous system; and retina. Used to study acute lymphoblastic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Kmt2a Products (1)

mRNA Protein Name
NM_001357549.2 NP_001344478.1 histone-lysine N-methyltransferase 2A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
24824656 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15640349 MGI
enables histone H3K4 methyltransferase activity IDA
IDA: Inferred from direct assay
12453418 MGI
enables histone H3K4 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
16618927 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16618927 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
15741318 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
16618927 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21113167 MGI
acts upstream of or within cognition IMP
IMP: Inferred from mutant phenotype
25834037 MGI
involved in definitive hemopoiesis IMP
IMP: Inferred from mutant phenotype
15556871 MGI
acts upstream of or within embryonic hemopoiesis IMP
IMP: Inferred from mutant phenotype
9639506 MGI
acts upstream of or within epigenetic regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16618927 MGI
acts upstream of or within exploration behavior IMP
IMP: Inferred from mutant phenotype
25834037 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
15640349 MGI
acts upstream of or within homeostasis of number of cells within a tissue IGI
IGI: Inferred from genetic interaction
22674806 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
15640349 MGI
acts upstream of or within peptidyl-lysine monomethylation IMP
IMP: Inferred from mutant phenotype
25834037 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21113167 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15640349 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12453418 MGI
acts upstream of or within post-embryonic development IGI
IGI: Inferred from genetic interaction
22674806 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25834037 MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
25834037 MGI
acts upstream of or within response to light stimulus IMP
IMP: Inferred from mutant phenotype
25834037 MGI
acts upstream of or within spleen development IGI
IGI: Inferred from genetic interaction
22674806 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
25834037 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11555636 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase 2A

  • cysteine methyltransferase KMT2A

  • histone-lysine N-methyltransferase MLL

  • myeloid/lymphoid or mixed-lineage leukemia protein 1

  • trithorax Drosophila

  • zinc finger protein HRX

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148669A Bleximenib oxalate 98.97% Phase 3

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148669 Bleximenib 99.36% Unkown
HY-156794 Enzomenib Inhibitor 99.88% Unkown
HY-172416 Balomenib Inhibitor 99.81% Unkown
HY-148669B (S)-Bleximenib oxalate Control 98.37% Unkown
HY-156794A Enzomenib enantiomer Inhibitor 98.01% Unkown
HY-148829 MS40 Degrader / Unkown
HY-170832 Menin–KMT2A-IN-1 Inhibitor / Unkown
HY-RS07401 KMT2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18528 Kmt2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25010 Kmt2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kmt2a NCBI NCBI:4297