Pak6 - p21 (RAC1) activated kinase 6 Gene

Also Known as 4732456M09

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214230

About Pak6

Chromosome 2: 118,493,784-118,528,501 forward strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 260 orthologues, 35 paralogues and is associated with 5 phenotypes. Broad expression in adrenal adult (RPKM 13.2), CNS E18 (RPKM 12.7) and 18 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within learning or memory; locomotory behavior; and neuron projection morphogenesis. Predicted to be located in cell junction; fibrillar center; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina; submandibular gland primordium; and tooth. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including BUB1B-PAK6 (BUB1B-PAK6 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Pak6 Products (2)

mRNA Protein Name
NM_001145854.1 NP_001139326.1 serine/threonine-protein kinase PAK 6
NM_001033254.3 NP_001028426.2 serine/threonine-protein kinase PAK 6

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within learning IGI
IGI: Inferred from genetic interaction
18675265 MGI
acts upstream of or within locomotory behavior IGI
IGI: Inferred from genetic interaction
18675265 MGI
acts upstream of or within memory IGI
IGI: Inferred from genetic interaction
18675265 MGI
acts upstream of or within neuron projection arborization IMP
IMP: Inferred from mutant phenotype
29117290 MGI
acts upstream of or within neuron projection extension IMP
IMP: Inferred from mutant phenotype
29117290 MGI
Cellular Component GO Annotation Evidence References Source
is active in postsynaptic density EXP
EXP: Inferred from Experiment
25211037 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
25211037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak6 Protein Structure

PBD

PBD: pfam00786 (10 - 66)

STKc_PAK6

STKc_PAK6: cd06659 (385 - 681)

  • 0
  • 200
  • 400
  • 600
  • 682 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 6

  • PAK-6

  • p21 protein (Cdc42/Rac)-activated kinase 6

  • p21-activated kinase 6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak6 NCBI NCBI:56924