PAK6 - p21 (RAC1) activated kinase 6 Gene

Homo sapiens

Also known as PAK5

Gene ID: 56924 | Gene type: protein coding

About PAK6

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,239,063-40,277,487 (from NCBI)

This gene has 20 transcripts (splice variants), 260 orthologues and 35 paralogues. Broad expression in testis (RPKM 8.7), brain (RPKM 8.5) and 14 other tissues.

Summary

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including Cytoskeleton rearrangement, Apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with Androgen Receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

PAK6 Products(5)

mRNA	Protein	Name
NM_001276717.1	NP_001263646.1	serine/threonine-protein kinase PAK 6 isoform 1
NM_001276718.2	NP_001263647.1	serine/threonine-protein kinase PAK 6 isoform 2
NM_001395430.1	NP_001382359.1	serine/threonine-protein kinase PAK 6 isoform 1
NM_020168.6	NP_064553.1	serine/threonine-protein kinase PAK 6 isoform 1
NM_001395431.1	NP_001382360.1	serine/threonine-protein kinase PAK 6 isoform 1

PAK6 Protein Structure

PBD

Pkinase

0
200
400
600
681 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 6

p21 protein (Cdc42/Rac)-activated kinase 6

p21(CDKN1A)-activated kinase 6

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Unkown
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PAK6	VGNC	VGNC:99207
Rattus norvegicus	PAK6	RGD	RGD:1306213
Mus musculus	PAK6	MGD	MGI:2679420
Others	PAK6	NCBI

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