PAK6 - p21 (RAC1) activated kinase 6 Gene

Also Known as PAK5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56924

About PAK6

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,239,063-40,277,487 (from NCBI)

This gene has 20 transcripts (splice variants), 260 orthologues and 35 paralogues. Broad expression in testis (RPKM 8.7), brain (RPKM 8.5) and 14 other tissues.

Summary

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including Cytoskeleton rearrangement, Apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with Androgen Receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

PAK6 Products (5)

mRNA Protein Name
NM_001276717.1 NP_001263646.1 serine/threonine-protein kinase PAK 6 isoform 1
NM_001276718.2 NP_001263647.1 serine/threonine-protein kinase PAK 6 isoform 2
NM_001395430.1 NP_001382359.1 serine/threonine-protein kinase PAK 6 isoform 1
NM_020168.6 NP_064553.1 serine/threonine-protein kinase PAK 6 isoform 1
NM_001395431.1 NP_001382360.1 serine/threonine-protein kinase PAK 6 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK6 Protein Structure

PBD

PBD: P21-Rho-binding domain (11 - 63)

Pkinase

Pkinase: Protein kinase domain (412 - 658)

  • 0
  • 200
  • 400
  • 600
  • 681 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 6

  • p21 protein (Cdc42/Rac)-activated kinase 6

  • p21(CDKN1A)-activated kinase 6

PAK6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83588 Phospho-PAK4/5/6 (Ser474/Ser560/Ser602) Antibody (YA3333) WB Human, Mouse, Rat
HY-P83588A Phospho-PAK4/5/6 (Ser474/Ser560/Ser602) Antibody (YA3333)(PBS only) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PAK6 VGNC VGNC:99207
Rattus norvegicus PAK6 RGD RGD:1306213
Mus musculus PAK6 MGD MGI:2679420
Others PAK6 NCBI