Arid5a - AT rich interactive domain 5A (MRF1-like) Gene

Also Known as Mrf1; D430024K22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 214855

Summary

Enables RNA stem-loop binding activity and chromatin binding activity. Involved in cellular response to lipopolysaccharide; positive regulation of T-helper 17 type immune response; and positive regulation of cytokine production. Acts upstream of or within chondrocyte differentiation; positive regulation of histone acetylation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including ear; heart; hemolymphoid system; nervous system; and neural retina. Orthologous to human ARID5A (AT-rich interaction domain 5A). [provided by Alliance of Genome Resources, Apr 2022]

Arid5a Products (5)

mRNA	Protein	Name
NM_001172205.1	NP_001165676.1	AT-rich interactive domain-containing protein 5A isoform 1
NM_001172206.1	NP_001165677.1	AT-rich interactive domain-containing protein 5A isoform 2
NM_001290726.1	NP_001277655.1	AT-rich interactive domain-containing protein 5A isoform 5
NM_001290727.1	NP_001277656.1	AT-rich interactive domain-containing protein 5A isoform 6
NM_145996.4	NP_666108.2	AT-rich interactive domain-containing protein 5A isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	27671645	MGI
enables RNA stem-loop binding	IMP IMP: Inferred from mutant phenotype	27022145	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	21346191	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21346191	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	21346191	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	27671645	MGI
acts upstream of or within chondrocyte differentiation	IDA IDA: Inferred from direct assay	21346191	MGI
involved in positive regulation of T-helper 1 cell cytokine production	IMP IMP: Inferred from mutant phenotype	27671645	MGI
involved in positive regulation of T-helper 17 type immune response	IMP IMP: Inferred from mutant phenotype	27022145	MGI
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	27022145	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	27671645	MGI
acts upstream of or within positive regulation of protein acetylation	IDA IDA: Inferred from direct assay	21346191	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21346191	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	27671645	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	27022145	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	21346191	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	21346191	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
AT-rich interactive domain-containing protein 5A	ARID domain-containing protein 5A AT rich interactive domain 5A (Mrf1 like) modulator recognition factor I

Arid5a Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Arid5a	Q3U108	SOX9	Homo sapiens	P48436	Confocal	21346191
Cross	Arid5a	Q3U108	SOX9	Homo sapiens	P48436	Anti Tag CoIP	21346191

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00973	ARID5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arid5a	NCBI	NCBI:10865