Micu1 - mitochondrial calcium uptake 1 Gene

Also Known as Calc; Cbara1; C730016L05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216001

Summary

Enables calcium ion binding activity and protein heterodimerization activity. Predicted to be involved in several processes, including calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and regulation of cellular hyperosmotic salinity response. Predicted to act upstream of or within calcium ion transport. Located in mitochondrion. Part of Calcium Channel complex. Is expressed in several structures, including genitourinary system; liver; nervous system; parathyroid gland; and respiratory system. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Apr 2022]

Micu1 Products (4)

mRNA Protein Name
NM_001291442.1 NP_001278371.1 calcium uptake protein 1, mitochondrial isoform 1
NM_001291443.1 NP_001278372.1 calcium uptake protein 1, mitochondrial isoform 2
NM_001359267.1 NP_001346196.1 calcium uptake protein 1, mitochondrial isoform 4
NM_144822.3 NP_659071.1 calcium uptake protein 1, mitochondrial isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IMP
IMP: Inferred from mutant phenotype
24560927 MGI
enables calcium ion sensor activity IDA
IDA: Inferred from direct assay
24560927 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24560927 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
24560927 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium import into the mitochondrion IDA
IDA: Inferred from direct assay
27818145 MGI
involved in calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
27477272 MGI
involved in positive regulation of cristae formation IDA
IDA: Inferred from direct assay
37098122 MGI
Cellular Component GO Annotation Evidence References Source
part of calcium channel complex IDA
IDA: Inferred from direct assay
23409044 MGI
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
30504268 MGI
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
30504268 MGI
is active in mitochondrion IDA
IDA: Inferred from direct assay
27818145 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcium uptake protein 1, mitochondrial

  • calcium binding atopy-related autoantigen 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08431 MICU1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19458 Micu1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25951 Micu1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Micu1 NCBI NCBI:10367