Socs2 - suppressor of cytokine signaling 2 Gene

Also Known as hg; JAB; CIS2; Cish2; SSI-2; SOCS-2; 8030460M17; D130043N08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216233

Summary

Enables growth hormone receptor binding activity. Acts upstream of or within several processes, including mammary gland development; negative regulation of receptor signaling pathway via JAK-STAT; and positive regulation of neuron differentiation. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including lung; primary sex cord; retina; and ureteric tip. Human ortholog(s) of this gene implicated in endometrial Cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Apr 2022]

Socs2 Products (4)

mRNA Protein Name
NM_001168655.1 NP_001162126.1 suppressor of cytokine signaling 2
NM_001168656.1 NP_001162127.1 suppressor of cytokine signaling 2
NM_001168657.1 NP_001162128.1 suppressor of cytokine signaling 2
NM_007706.4 NP_031732.1 suppressor of cytokine signaling 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables growth hormone receptor binding IPI
IPI: Inferred from physical interaction
15690087 MGI
enables phosphorylation-dependent protein binding IMP
IMP: Inferred from mutant phenotype
15690087 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
31578312 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell surface receptor signaling pathway via JAK-STAT IGI
IGI: Inferred from genetic interaction
16469767 MGI
acts upstream of or within intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
15690087 MGI
acts upstream of or within lactation IGI
IGI: Inferred from genetic interaction
11445538 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
11445538 MGI
acts upstream of or within mammary gland alveolus development IGI
IGI: Inferred from genetic interaction
11445538 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
11445538 MGI
involved in negative regulation of growth hormone receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12040024 MGI
acts upstream of or within negative regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
15690087 MGI
acts upstream of or within negative regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
15690087 MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT IGI
IGI: Inferred from genetic interaction
16469767 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
12368809 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
11401434 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

suppressor of cytokine signaling 2

  • CIS-2

  • STAT-induced STAT inhibitor 2

  • cytokine inducible SH2-containing protein 2

  • cytokine-inducible SH2 protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156395 MN551 Inducer 98.01% Unkown
HY-156373 MN714 Inhibitor 99.12% Unkown
HY-173364 EB-TCIP Inducer 99.58% Unkown
HY-RS13553 SOCS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18546 Socs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25028 Socs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Socs2 NCBI NCBI:8835