Tdg - thymine DNA glycosylase Gene

Also Known as Jza1; JZA-3; E130317C12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21665

Summary

Enables several functions, including SUMO binding activity; protein kinase C binding activity; and transcription coregulator activity. Involved in DNA metabolic process; regulation of embryonic development; and regulation of gene expression, epigenetic. Acts upstream of or within negative regulation of chromatin binding activity; negative regulation of protein binding activity; and negative regulation of transcription by RNA polymerase II. Located in PML body. Is expressed in several structures, including epithelium; genitourinary system; nervous system; retina; and skin. Orthologous to human TDG (thymine DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]

Tdg Products (3)

mRNA Protein Name
NM_001358517.1 NP_001345446.1 G/T mismatch-specific thymine DNA glycosylase isoform 3
NM_011561.3 NP_035691.2 G/T mismatch-specific thymine DNA glycosylase isoform 1
NM_172552.4 NP_766140.2 G/T mismatch-specific thymine DNA glycosylase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
21722948 MGI
enables DNA binding IDA
IDA: Inferred from direct assay
21817016 MGI
enables SUMO binding IPI
IPI: Inferred from physical interaction
15569683 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16282588 MGI
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
19966277 MGI
enables transcription coregulator activity IGI
IGI: Inferred from genetic interaction
18945672 MGI
Biological Process GO Annotation Evidence References Source
involved in base-excision repair IDA
IDA: Inferred from direct assay
21817016 MGI
involved in epigenetic regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21278727 MGI
acts upstream of or within negative regulation of chromatin binding IDA
IDA: Inferred from direct assay
18945672 MGI
acts upstream of or within negative regulation of protein binding IDA
IDA: Inferred from direct assay
18945672 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18945672 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18945672 MGI
involved in regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
21278727 MGI
Cellular Component GO Annotation Evidence References Source
located in PML body IDA
IDA: Inferred from direct assay
15569683 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15569683 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G/T mismatch-specific thymine DNA glycosylase

  • C-JUN leucine zipper interactive protein JZA-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130208 Thiodigalactoside Inhibitor 99.89% Unkown
HY-126181 5-Formylcytosine 96.4% Unkown
HY-181440 TDG-IN-1 Inhibitor / Unkown
HY-RS14329 TDG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17123 Tdg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23568 Tdg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tdg NCBI NCBI:6996