Ggnbp2 - gametogenetin binding protein 2 Gene

Also Known as DIF-3; Zfp403; D330017P12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 217039

Summary

Acts upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and spleen. Orthologous to human GGNBP2 (gametogenetin binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ggnbp2 Products (5)

mRNA	Protein	Name
NM_001364111.1	NP_001351040.1	gametogenetin-binding protein 2 isoform 1
NM_001364112.1	NP_001351041.1	gametogenetin-binding protein 2 isoform 2
NM_001364114.1	NP_001351043.1	gametogenetin-binding protein 2 isoform 4
NM_001364115.1	NP_001351044.1	gametogenetin-binding protein 2 isoform 4
NM_153144.3	NP_694784.2	gametogenetin-binding protein 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15642376	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell differentiation	IDA IDA: Inferred from direct assay	26764350	MGI
acts upstream of or within labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	26764350	MGI
acts upstream of or within labyrinthine layer development	IMP IMP: Inferred from mutant phenotype	26764350	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	26764350	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	26764350	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	26764350	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26764350	MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	26764350	MGI
acts upstream of or within negative regulation of protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	26764350	MGI
acts upstream of or within negative regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	26764350	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15642376	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11728448	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
gametogenetin-binding protein 2	dioxin inducible factor 3 gametogenin binding protein 2 zinc finger protein 403

Ggnbp2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ggnbp2	Q5SV77	Ggn	Mus musculus	Q80WJ1	Anti Tag CoIP	15642376
Intra	Ggnbp2	Q5SV77	Ggn	Mus musculus	Q80WJ1	Y2H	15642376

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05401	GGNBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ggnbp2	NCBI	NCBI:79893