Trim25 - tripartite motif-containing 25 Gene

Also Known as EFP; Zfp147

Species: Mus musculus

Gene Type: protein coding
Gene ID: 217069

Summary

Predicted to enable RIG-I binding activity; transcription coactivator activity; and ubiquitin protein Ligase activity. Involved in defense response to Other organism; negative regulation of viral entry into host cell; and regulation of protein localization. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human TRIM25 (tripartite motif containing 25). [provided by Alliance of Genome Resources, Apr 2022]

Trim25 Products (1)

mRNA Protein Name
NM_009546.2 NP_033572.2 E3 ubiquitin/ISG15 ligase TRIM25

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29125140 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
18248090 MGI
involved in negative regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
18248090 MGI
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
29125140 MGI
involved in suppression of viral release by host IDA
IDA: Inferred from direct assay
18248090 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11331580 MGI
located in nucleus IDA
IDA: Inferred from direct assay
29125140 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin/ISG15 ligase TRIM25

  • RING-type E3 ubiquitin transferase TRIM25

  • estrogen-responsive finger protein

  • tripartite motif protein 25

  • tripartite motif-containing protein 25

  • ubiquitin/ISG15-conjugating enzyme TRIM25

  • zinc finger protein 147

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162065 N6F11 Inducer 98.11% Unkown
HY-RS15030 TRIM25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174853 TRIM25 ligand-1 Ligand / Unkown
HY-177815 R-1 sodium Inhibitor / Unkown
HY-177816 R-2 sodium Inhibitor / Unkown
HY-183638 T7117 Inhibitor / Unkown
HY-RS18314 Trim25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24792 Trim25 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trim25 NCBI NCBI:7706