Trib2 - tribbles pseudokinase 2 Gene

Also Known as TRB2; TRB-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 217410

Summary

Enables ubiquitin protein Ligase binding activity and ubiquitin-protein transferase regulator activity. Involved in negative regulation of fat cell differentiation and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and Cytoskeleton. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and integumental system. Orthologous to human TRIB2 (tribbles pseudokinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Trib2 Products (1)

mRNA Protein Name
NM_144551.6 NP_653134.2 tribbles homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
17576771 MGI
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
20410507 MGI
enables ubiquitin-protein transferase regulator activity IDA
IDA: Inferred from direct assay
20410507 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
17576771 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20410507 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tribbles homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168274 PROTAC TRIB2 degrader-1 Inducer / Unkown
HY-184178A HF-125 Inducer / Unkown
HY-168275 TRIB2 ligand-1 Ligand / Unkown
HY-168276 Boc-Nonanol / Unkown
HY-168277 5-Aminothalidomide-C9-Boc / Unkown
HY-RS15016 TRIB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19489 Trib2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25983 Trib2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trib2 NCBI NCBI:28951