Tie1 - tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Gene

Also Known as TIE; tie-1; D430008P04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21846

Summary

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in circulatory system development; response to retinoic acid; and tissue remodeling. Acts upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Tie1 Products (1)

mRNA Protein Name
NM_011587.2 NP_035717.2 tyrosine-protein kinase receptor Tie-1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
31319059 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
23918385 MGI
involved in branching involved in lymph vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
20223757 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
11172728 MGI
acts upstream of or within lymphatic endothelial cell differentiation IMP
IMP: Inferred from mutant phenotype
20223757 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
9683559 MGI
acts upstream of or within negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
9683559 MGI
acts upstream of or within plasma membrane fusion IMP
IMP: Inferred from mutant phenotype
9683559 MGI
acts upstream of or within regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20223757 MGI
acts upstream of regulation of extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
31319059 MGI
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
18439490 MGI
involved in tissue remodeling IMP
IMP: Inferred from mutant phenotype
20223757 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
17717145 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase receptor Tie-1

  • tyrosine kinase receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117733 Zerumin A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tie1 NCBI NCBI:7075