TIE1 - tyrosine kinase with immunoglobulin like and EGF like domains 1 Gene

Also Known as TIE; JTK14; LMPHM11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7075

About TIE1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,300,982-43,323,108 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues, 53 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 23.3), fat (RPKM 19.2) and 21 other tissues.

Summary

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

TIE1 Products (2)

mRNA Protein Name
NM_001253357.2 NP_001240286.1 tyrosine-protein kinase receptor Tie-1 isoform 2
NM_005424.5 NP_005415.1 tyrosine-protein kinase receptor Tie-1 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIE1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (135 - 197)

hEGF

hEGF: Human growth factor-like EGF (243 - 255)

Ig_2

Ig_2: Immunoglobulin domain (370 - 443)

fn3

fn3: Fibronectin type III domain (455 - 531)

fn3

fn3: Fibronectin type III domain (557 - 631)

fn3

fn3: Fibronectin type III domain (645 - 728)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (840 - 1106)

  • 0
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  • 1000
  • 1138 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase receptor Tie-1

  • tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1

TIE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TIE1 P35590 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
TIE1 P35590 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
TIE1 P35590 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
TIE1 P35590 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
TIE1 P35590 PSG5 Homo sapiens Q15238
SPR
21982860
Intra
TIE1 P35590 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
TIE1 P35590 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
TIE1 P35590 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
TIE1 P35590 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra
TIE1 P35590 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra
TIE1 P35590 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TIE1 Proteins

Cat. No. Product Name Accession Purity
HY-P71362 TIE-1 Protein, Human (HEK293, His) P35590 (A22-Q760) ≥ 90%, as determined by reducing SDS-PAGE.

TIE1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84276 TIE1 Antibody (YA3973) IHC-P, ELISA Human
HY-P84276A TIE1 Antibody (YA3973)(PBS only) WB, IHC-P, ELISA Human

Related Diseases

Diseases Alias
Lymphatic Malformation 11

  • LMPHM11
Angiosarcoma

  • Hemangiosarcoma
Malignant Renovascular Hypertension

  • Secondary Malignant Renovascular Hypertension
Primary Lymphedema

  • Lymphedema Primary
Inflammatory Breast Carcinoma

  • Inflammatory Breast Cancer

  • Inflammatory Carcinoma Of Breast

  • Mastitis Carcinomatosa

  • Breast Cancer, Inflammatory

  • Inflammatory Breast Neoplasms

  • Inflammatory Adenocarcinoma Of Breast
Breast Angiosarcoma

  • Angiosarcoma Of The Breast

  • Hemangiosarcoma Of The Breast

  • Primary Angiosarcoma Of Breast
Periodontosis

  • Periodontitis, Juvenile

  • Parodontosis

  • Paradentosis
Lymphangiosarcoma

  • Skin Lymphangiosarcoma

  • Stewart Treves Syndrome

  • Lymphangiosarcoma Of Stewart And Treves

  • Malignant Lymphangioendothelioma

  • Stewart-Treves Syndrome
Hemangioma

  • Hemangiomas
Malignant Secondary Hypertension
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117733 Zerumin A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TIE1 VGNC VGNC:47366
Mus musculus TIE1 MGD MGI:99906
Bos taurus TIE1 VGNC VGNC:35861
Rattus norvegicus TIE1 RGD RGD:621642
Felis catus TIE1 VGNC VGNC:80380
Macaca mulatta TIE1 VGNC VGNC:78355
Others TIE1 NCBI