Timp1 - tissue inhibitor of metalloproteinase 1 Gene

Also Known as EPA; Clgi; Timp; TIMP-1; TPA-S1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21857

Summary

Predicted to enable several functions, including cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Located in basement membrane. Is expressed in several structures, including early conceptus; hindlimb cartilage condensation; jaw; reproductive system; and skeletal system. Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Timp1 Products (3)

mRNA Protein Name
NM_001044384.1 NP_001037849.1 metalloproteinase inhibitor 1 isoform a precursor
NM_001294280.2 NP_001281209.1 metalloproteinase inhibitor 1 isoform b
NM_011593.2 NP_035723.2 metalloproteinase inhibitor 1 isoform a precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within connective tissue replacement involved in inflammatory response wound healing IDA
IDA: Inferred from direct assay
23100531 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
12950084 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
12950084 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloproteinase inhibitor 1

  • TPA-induced protein

  • collagenase inhibitor 16C8 fibroblast

  • erythroid-potentiating activity

  • tissue inhibitor of metalloproteinases 1

Recombinant Timp1 Proteins

Cat. No. Product Name Accession Purity
HY-P71110 TIMP-1 Protein, Mouse (HEK293) P12032 (C25-R205) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-154919 DC-Y13-27 99.52% Unkown
HY-151932 FXR agonist 3 Agonist 96.51% Unkown
HY-47888 PLN-1474 Inhibitor 99.35% Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-172258 5-HT2B antagonist-2 Inhibitor / Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-N19029 Vernodalin / Unkown
HY-RS14538 TIMP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162902 ALK5-IN-82 Inhibitor / Unkown
HY-RS16840 Timp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23282 Timp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992307 Anti-TIMP-1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Timp1 NCBI NCBI:7076