LRRC55 - leucine rich repeat containing 55 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 219527

About LRRC55

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,181,953-57,191,717 (from NCBI)

This gene has 2 transcripts (splice variants), 119 orthologues and 25 paralogues. Broad expression in brain (RPKM 2.8), lymph node (RPKM 1.5) and 14 other tissues.

Summary

Enables Potassium Channel activator activity; transmembrane transporter binding activity; and voltage-gated Potassium Channel activity. Involved in positive regulation of voltage-gated Potassium Channel activity and potassium ion transmembrane transport. Part of voltage-gated Potassium Channel complex. [provided by Alliance of Genome Resources, Apr 2022]

LRRC55 Products (1)

mRNA	Protein	Name
NM_001005210.4	NP_001005210.2	leucine-rich repeat-containing protein 55 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables potassium channel activator activity	IDA IDA: Inferred from direct assay	22547800	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	22547800	GOA
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	22547800	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	22547800	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	22547800	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	22547800	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC55 Protein Structure

LRRNT

LRR_8

0
100
200
300
341 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat-containing protein 55	BK channel auxiliary gamma subunit LRRC55

Related Diseases

Diseases	Alias
Lymph Node Carcinoma	Lymph Node Cancer Lymph Node Neoplasm Neoplasm Of Lymph Node

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07823	LRRC55 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LRRC55	VGNC	VGNC:82022
Macaca mulatta	LRRC55	VGNC	VGNC:107455
Mus musculus	LRRC55	MGD	MGI:2685197
Canis familiaris	LRRC55	VGNC	VGNC:42805
Bos taurus	LRRC55	VGNC	VGNC:31022
Rattus norvegicus	LRRC55	RGD	RGD:1561726