FAU - FAU ubiquitin like and ribosomal protein S30 fusion Gene

Also Known as S30; FAU1; Fub1; Fubi; asr1; RPS30; MNSFbeta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2197

About FAU

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,120,630-65,122,134 (from NCBI)

This gene has 9 transcripts (splice variants) and 265 orthologues. Ubiquitous expression in ovary (RPKM 446.2), bone marrow (RPKM 364.4) and 25 other tissues.

Summary

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the Ubiquitin-Like Protein FUBI at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]

FAU Products (1)

mRNA Protein Name
NM_001997.5 NP_001988.1 FAU ubiquitin-like and ribosomal protein S30 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Biological Process GO Annotation Evidence References Source
involved in antibacterial humoral response IDA
IDA: Inferred from direct assay
12860195 GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
12860195 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
12860195 GOA
involved in innate immune response in mucosa IDA
IDA: Inferred from direct assay
12860195 GOA
involved in ribosomal small subunit assembly IDA
IDA: Inferred from direct assay
34318747 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
8706699 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
12860195 GOA
located in nucleus IDA
IDA: Inferred from direct assay
34318747 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAU Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (9 - 70)

Ribosomal_S30

Ribosomal_S30: Ribosomal protein S30 (75 - 133)

  • 0
  • 100
  • 133 a.a.
Protein Preferred Names Protein Names

FAU ubiquitin-like and ribosomal protein S30

  • 40S ribosomal protein S30

Recombinant FAU Proteins

Cat. No. Product Name Accession Purity
HY-P71681 FAU Protein, Human (GST) P62861/NM_001997 (M1-S133) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Osteogenic Sarcoma

  • Osteosarcoma

  • OSRC

  • Osteosarcoma, Somatic

  • Neoplasms, Bone Tissue

  • Bone Tissue Neoplasm

  • Osteoid Sarcoma

  • Skeletal Sarcoma

  • Osteosarcoma Of Bone

  • Bone Sarcoma
Eosinophilic Meningitis

  • Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04765 FAU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18893 Fau Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25384 Fau Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FAU VGNC VGNC:101085
Canis familiaris FAU VGNC VGNC:51871
Mus musculus FAU MGD MGI:102547
Rattus norvegicus FAU RGD RGD:61938
Others FAU NCBI