SLC37A2 - solute carrier family 37 member 2 Gene

Also Known as SPX2; pp11662

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 219855

About SLC37A2

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,063,305-125,090,516 (from NCBI)

This gene has 6 transcripts (splice variants), 241 orthologues and 12 paralogues. Broad expression in adrenal (RPKM 13.0), salivary gland (RPKM 12.4) and 18 other tissues.

Summary

Enables glucose 6-phosphate:inorganic phosphate antiporter activity. Involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC37A2 Products (2)

mRNA	Protein	Name
NM_001145290.2	NP_001138762.1	glucose-6-phosphate exchanger SLC37A2 isoform 2
NM_198277.3	NP_938018.1	glucose-6-phosphate exchanger SLC37A2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables glucose 6-phosphate:phosphate antiporter activity	EXP EXP: Inferred from Experiment	21949678	GOA
enables glucose 6-phosphate:phosphate antiporter activity	IDA IDA: Inferred from direct assay	21949678	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in glucose-6-phosphate transport	IDA IDA: Inferred from direct assay	21949678	GOA
involved in phosphate ion transmembrane transport	IDA IDA: Inferred from direct assay	21949678	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21949678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC37A2 Protein Structure

MFS_1

0
100
200
300
400
501 a.a.

Protein Preferred Names	Protein Names
glucose-6-phosphate exchanger SLC37A2	solute carrier family 37 (glucose-6-phosphate transporter), member 2

Related Diseases

Diseases	Alias
Caffey Disease	Infantile Cortical Hyperostosis CAFYD Cortical Congenital Hyperostosis Caffey-Silverman Syndrome De Toni-Caffey Disease Hyperostosis Cortical Infantile Hyperostosis, Cortical, Congenital
Van Den Ende-Gupta Syndrome	VDEGS Blepharophimosis, Arachnodactyly, And Congenital Contractures Marden-Walker-Like Syndrome Marden-Walker-Like Syndrome Without Psychomotor Retardation Marden Walker Like Syndrome Marden-Walker-Like Syndrome Without Psychmotor Retardation Van Den Ende Gupta Syndrome Marden Walker Like Syndrome Without Psychomotor Retardation Blepharophimosis Arachnodactyly And Congenital Contractures
Combined Oxidative Phosphorylation Deficiency 24	COXPD24 Combined Oxidative Phosphorylation Defect Type 24 Oxidative Phosphorylation Deficiency, Combined, Type 24
Combined Oxidative Phosphorylation Deficiency 20	COXPD20 Combined Oxidative Phosphorylation Defect Type 20 Oxidative Phosphorylation Deficiency, Combined, Type 20

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-119384	Promegestone	Agonist	99.14%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS13214	SLC37A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18882	Slc37a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25373	Slc37a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC37A2	VGNC	VGNC:34843
Mus musculus	SLC37A2	MGD	MGI:1929693
Macaca mulatta	SLC37A2	VGNC	VGNC:107645
Felis catus	SLC37A2	VGNC	VGNC:81937
Canis familiaris	SLC37A2	VGNC	VGNC:46387
Rattus norvegicus	SLC37A2	RGD	RGD:1564160
Others	SLC37A2	NCBI