FCER2 - Fc epsilon receptor II Gene

Also Known as CD23; FCE2; CD23A; IGEBF; CLEC4J; FCErII; BLAST-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2208

About FCER2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,688,776-7,702,131 (from NCBI)

This gene has 7 transcripts (splice variants), 861 orthologues and 14 paralogues. Biased expression in spleen (RPKM 20.9), lymph node (RPKM 16.3) and 4 other tissues.

Summary

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

FCER2 Products (3)

mRNA Protein Name
NM_001207019.3 NP_001193948.2 low affinity immunoglobulin epsilon Fc receptor isoform b
NM_001220500.2 NP_001207429.1 low affinity immunoglobulin epsilon Fc receptor isoform a
NM_002002.5 NP_001993.2 low affinity immunoglobulin epsilon Fc receptor isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables IgE binding IDA
IDA: Inferred from direct assay
16172256 GOA
enables low-affinity IgE receptor activity IDA
IDA: Inferred from direct assay
7544003 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
12777399 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16172256 GOA
Biological Process GO Annotation Evidence References Source
involved in B cell antigen processing and presentation IDA
IDA: Inferred from direct assay
2167225 GOA
involved in Fc receptor-mediated immune complex endocytosis IDA
IDA: Inferred from direct assay
2167225 GOA
involved in macrophage activation IDA
IDA: Inferred from direct assay
7544003 GOA
involved in positive regulation of killing of cells of another organism IDA
IDA: Inferred from direct assay
7544003 GOA
involved in positive regulation of nitric-oxide synthase activity IDA
IDA: Inferred from direct assay
7544003 GOA
involved in positive regulation of nitric-oxide synthase biosynthetic process IDA
IDA: Inferred from direct assay
7544003 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
7544003 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCER2 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (182 - 283)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
Protein Preferred Names Protein Names

low affinity immunoglobulin epsilon Fc receptor

  • C-type lectin domain family 4, member J

FCER2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FCER2 P06734 ATF7 Homo sapiens P17544
Y2H Prey Pooling
25416956
Intra
FCER2 P06734 ATF7 Homo sapiens P17544
Validated Y2H
25416956
Intra
FCER2 P06734 ATF7 Homo sapiens P17544
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCER2 Proteins

Cat. No. Product Name Accession Purity
HY-P72748 CD23/Fc epsilon RII Protein, Human (HEK293, His) P06734 (D48-S321) ≥ 95%, as determined by reducing SDS-PAGE.

FCER2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81551 CD23 Antibody (YA1296) IHC-P, ICC/IF, FC Human
HY-P84977 CD23 Antibody (YA4669) ELISA, FC Human
HY-P85973 CD23 Antibody (YA5665) IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Extrinsic Allergic Alveolitis

  • Hypersensitivity Pneumonitis

  • Alveolitis, Extrinsic Allergic

  • Alveolitis

  • Allergic Interstitial Pneumonitis

  • Allergic Pneumonitis

  • Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis

  • Hp

  • Pneumonitis Hypersensitivity

  • Allergic Alveolitis

  • Extrinsic Allergic Alveolitis Nos

  • Airway Obstruction With Allergic Alveolitis

  • Unspecified Allergic Alveolitis And Pneumonitis

  • Extrinsic Allergic Bronchiolo-Alveolitis

  • Hypersensitivity Pneumonia

  • Hypersensitivity Pneumonitis Nos

  • Obstructive Lung Disease With Allergic Alveolitis

  • Obstructive Lung Disorder With Hypersensitivity Pneumonitis

  • Obstructive Lung Disorder With Allergic Alveolitis

  • Obstructive Lung Disease With Hypersensitivity Pneumonitis
Chronic Conjunctivitis
Intrinsic Asthma

  • Non-Atopic Asthma
Leukemia, Chronic Lymphocytic 2

  • Leukemia, Chronic Lymphocytic, Susceptibility To, 2

  • B-Cell Malignancy, Low-Grade

  • Clls2

  • Disrupted In B-Cell Malignancy

  • Dbm

  • Leukemia, Chronic Lymphocytic, B-Cell

  • Bcll

  • Lymphocytic Leukemia Chronic B-Cell

  • Chronic Lymphocytic Leukemia

  • Chronic Lymph Leukaemia

  • Chronic Lymphatic Leukaemia

  • Chronic Lymphocytic Leukaemia

  • Chronic Lymphoid Leukaemia

  • Lymphoplasmacytic Leukaemia
Cutaneous Leishmaniasis

  • Diffuse Cutaneous Leishmaniasis

  • Asian Desert Cutaneous Leishmaniasis

  • Leishmaniasis, Cutaneous

  • Leproid Leishmaniasis

  • Leishmaniasis Diffuse Cutaneous

  • Leishmaniasis Cutaneous

  • Ethiopian Cutaneous Leishmaniasis

  • Old World Cutaneous Leishmaniasis
Urticaria

  • Nettle Rash

  • Hives

  • Wheal

  • Urticaria Nos
Allergic Rhinitis

  • Hay Fever

  • Allergic Rhinitis, Susceptibility To

  • ALRH

  • Atopic Rhinitis

  • Seasonal Allergic Rhinitis

  • Non-Seasonal Allergic Rhinitis

  • Perenial Allergic Rhinitis

  • Pollenosis

  • Rhinitis Allergic Seasonal

  • Rhinitis, Allergic, Perennial

  • Allergic Rhinitis, Cause Unspecified

  • Pollinosis

  • Pollen Allergy

  • Allergy Nos Due To Pollen

  • Summer Catarrh

  • Other Seasonal Allergic Rhinitis
Follicular Lymphoma

  • Lymphoma, Follicular

  • Lymphoma Follicular

  • Brill-Symmers' Disease

  • Large Cell Follicular Non-Hodgkin Lymphoma

  • Diffuse Follicle Centre Lymphoma

  • Diffuse Follicular Lymphoma Nos

  • Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

  • Follicular Large Cell Cleaved Or Noncleaved Lymphoma

  • Large Cell Follicular Noncleaved Lymphoma

  • Follicular Lymphoma With Or Without Diffuse Areas

  • Histiocytic Follicular Lymphoma

  • Histiocytic Nodular Lymphoma

  • Histiocytic Nodular Malignant Lymphoma

  • Large Cell Follicular Lymphoma

  • Large Cell Noncleaved Follicular Lymphoma

  • Large Cell Noncleaved Follicular Malignant Lymphoma

  • Nodular Reticulum Cell Sarcoma

  • Noncleaved Follicular Lymphoma
Allergic Disease

  • Hypersensitivity

  • Allergic Hypersensitivity Disease

  • Allergic Condition

  • Allergic Reaction

  • Allergic Disposition
Rhinitis

  • Runny Nose
Bullous Pemphigoid

  • Benign Pemphigus

  • Senile Dermatitis Herpetiformis

  • Old Age Pemphigus

  • Parapemphigus

  • Pemphigoid

  • Pemphigoid Bullous

  • Pemphigoid, Bullous
Onchocerciasis

  • Infection By Onchocerca Volvulus

  • River Blindness

  • Onchocerca Volvulus Infection

  • Volvulosis

  • Robles' Disease

  • Onchocerciasis, Ocular

  • Robles Disease

  • Onchocercosis

  • Blinding Filariasis

  • Robles

  • Onchocerca Infestation

  • Craw-Craw
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Chronic Spontaneous Urticaria

  • Chronic Idiopathic Urticaria
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Castleman Disease

  • Angiofollicular Ganglionic Hyperplasia

  • Angiofollicular Lymph Hyperplasia

  • Giant Lymph Node Hyperplasia

  • Castleman'S Disease

  • Angiofollicular Lymph Node Hyperplasia

  • Lymphoid Hamartoma

  • Benign Giant Lymphoma

  • Angiolymphoid Hyperplasia
Prolymphocytic Leukemia

  • Pll

  • Prolymphocytic Leukaemia

  • Leukemia Prolymphocytic

  • Leukemia, Prolymphocytic
B-Cell Lymphoma

  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos
B-Cell Expansion With Nfkb And T-Cell Anergy

  • Benta Disease

  • BENTA

  • B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease

  • Persistent Polyclonal B-Cell Lymphocytosis

  • Lymphocytosis
Dermatitis

  • Eczema

  • Skin Inflammation

  • Inflammatory Dermatosis
Chronic Urticaria

  • Urticaria Chronic

  • Chronic Spontaneous Urticaria

  • Chronic Ordinary Urticaria
Combined Immunodeficiency

  • Combined T Cell And B Cell Immunodeficiency

  • Congenital Combined Immunodeficiency

  • Syndrome With Combined Immunodeficiency

  • Combined T And B Cell Immunodeficiency

  • Combined Immunity Deficiency

  • Combined Immunodeficiency Syndrome

  • Combined T-Cell And B-Cell Immunodeficiency

  • Lymphopenic Agammaglobulinaemia
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Dyskeratosis Congenita

  • Dyskeratosis Congenita Autosomal Dominant

  • Dc

  • Dkc

  • Zinsser-Engman-Cole Syndrome

  • Dyskeratosis Congenita, Autosomal Dominant

  • Autosomal Dominant Dyskeratosis Congenita

  • Dkca

  • Dyskeratosis Congenita Scoggins Type

  • Zinsser-Cole-Engman Syndrome

  • X-Linked Dyskeratosis Congenita

  • Hoyeraal-Hreidarsson Syndrome
Chronic Asthma
Lymphoma, Non-Hodgkin, Familial

  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04824 FCER2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24164 Fcer2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FCER2 VGNC VGNC:49895
Rattus norvegicus FCER2 RGD RGD:619997
Bos taurus FCER2 VGNC VGNC:28932
Felis catus FCER2 VGNC VGNC:82429
Mus musculus FCER2 MGD MGI:95497
Others FCER2 NCBI