Tsg101 - tumor susceptibility gene 101 Gene

Also Known as CC2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22088

Summary

Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate Cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Apr 2022]

Tsg101 Products (3)

mRNA	Protein	Name
NM_001348088.1	NP_001335017.1	tumor susceptibility gene 101 protein isoform 2
NM_001348089.1	NP_001335018.1	tumor susceptibility gene 101 protein isoform 3
NM_021884.4	NP_068684.1	tumor susceptibility gene 101 protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10888872	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	10888872	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell differentiation	IDA IDA: Inferred from direct assay	11943869	MGI
involved in exosomal secretion	IMP IMP: Inferred from mutant phenotype	25392495	MGI
acts upstream of or within keratinocyte differentiation	IDA IDA: Inferred from direct assay	11943869	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11943869	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10888872	MGI
involved in positive regulation of ubiquitin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	11916981	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	11943869	MGI
acts upstream of or within regulation of cell growth	IDA IDA: Inferred from direct assay	11943869	MGI
involved in viral budding	IMP IMP: Inferred from mutant phenotype	15256501	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15256501	MGI
located in extracellular exosome	IDA IDA: Inferred from direct assay	24205035	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tumor susceptibility gene 101 protein	ESCRT-I complex subunit TSG101

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17421	Tenatoprazole	Inhibitor	99.79%	Unkown
HY-RS15142	TSG101 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19082	Tsg101 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10845	KRL74	Inhibitor	/	Unkown
HY-RS25573	Tsg101 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991414	FGI-1011A6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tsg101	NCBI	NCBI:7251