Tyrp1 - tyrosinase-related protein 1 Gene

Also Known as b; isa; Oca3; TRP1; Tyrp; TRP-1; brown

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22178

Summary

Enables protein homodimerization activity. Involved in positive regulation of melanin biosynthetic process. Acts upstream of or within several processes, including acetoacetic acid metabolic process; melanocyte differentiation; and melanosome organization. Located in melanosome membrane. Is expressed in several structures, including hip; nervous system; sensory organ; skeleton; and skin. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (Tyrosinase related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Tyrp1 Products (3)

mRNA Protein Name
NM_001282014.1 NP_001268943.1 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor
NM_001282015.1 NP_001268944.1 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor
NM_031202.3 NP_112479.1 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
9918801 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9918801 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9918801 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within acetoacetic acid metabolic process IMP
IMP: Inferred from mutant phenotype
7665913 MGI
acts upstream of or within melanin metabolic process IMP
IMP: Inferred from mutant phenotype
9548375 MGI
acts upstream of or within melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
2379821 MGI
acts upstream of or within melanosome organization IMP
IMP: Inferred from mutant phenotype
9548375 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
2379821 MGI
involved in positive regulation of melanin biosynthetic process IGI
IGI: Inferred from genetic interaction
21949658 MGI
Cellular Component GO Annotation Evidence References Source
located in melanosome IDA
IDA: Inferred from direct assay
9918801 MGI
located in melanosome membrane IDA
IDA: Inferred from direct assay
17182842 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5,6-dihydroxyindole-2-carboxylic acid oxidase

  • DHICA oxidase

  • brown locus protein

  • catalase B

  • iris stromal atrophy

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99622 Flanvotumab Inhibitor ≥99.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N6069 Raspberry ketone glucoside Activator 99.52% Unkown
HY-RS15310 TYRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-161612 Mycosporine 2 glycine Inhibitor / Unkown
HY-RS18847 Tyrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25339 Tyrp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990149 Anti-Mouse/Human TYRP1 Antibody (TA99) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tyrp1 NCBI NCBI:7306