2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Anti-Mouse/Human TYRP1 Antibody (TA99)

Anti-Mouse/Human TYRP1 Antibody (TA99) 

Cat. No.: HY-P990149
Technical Support

Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8+ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma.

Para uso exclusivo en investigación. No vendemos a pacientes.

Anti-Mouse/Human TYRP1 Antibody (TA99)

Anti-Mouse/Human TYRP1 Antibody (TA99) Estructura química

Tamaño Stock
1 mg   Obtener un presupuesto  
5 mg   Obtener un presupuesto  
10 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Anti-Mouse/Human TYRP1 Antibody (TA99) Related Antibodies

Top Publications Citing Use of Products

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8+ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma[1].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Human/Mouse
IC50 & Target

TYRP1
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Human TYRP1 Antibody (TA99) Related Antibodies
In Vivo

Anti-Mouse/Human TYRP1 Antibody (TA99) (450 μg, i.p., at days 4, 11,18) shows potent anti-tumor effect companied with Tyrp1 or gp100 DNA vaccine in B16 melanoma mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16 melanoma mice models[1]
Dosage: 450 μg
Administration: Intraperitoneally injection, at days 4, 11,18 companied with Tyrp1 or gp100 DNA vaccine
Result: Revealed a significant reduction in tumor burden.
Showed a 2 fold increase in the CD8+T cell response against Tyrp1455-463 in the spleens depending on Fc receptor.
Localized rapidly and specifically to tumor nodules.
Enhanced infiltration of the tumor by CD8+ T cells.
Gene ID

22178  [NCBI]

Accession
Application

in vivo triggering of FcγRs; Immunofluorescence; Flow cytometry
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

150 kDa

SMILES

[Anti-Mouse/Human TYRP1 Antibody (TA99)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Mouse/Human TYRP1 Antibody (TA99) Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human TYRP1 Antibody (TA99)TyrosinaseTYRP1CD8+ T cellsCancerMelanomaB16Inhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
Anti-Mouse/Human TYRP1 Antibody (TA99)
Cat. No.:
HY-P990149
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.