Upp1 - uridine phosphorylase 1 Gene

Also Known as Up; Upp; UPase; UdRPase

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22271

Summary

Enables deoxyuridine Phosphorylase activity; thymidine Phosphorylase activity; and uridine Phosphorylase activity. Involved in pyrimidine nucleoside monophosphate metabolic process and uridine catabolic process. Acts upstream of or within pyrimidine nucleotide metabolic process and uridine metabolic process. Located in cytosol. Is expressed in early embryo; extraembryonic ectoderm; nervous system; and sensory organ. Orthologous to human UPP1 (uridine Phosphorylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Upp1 Products (3)

mRNA Protein Name
NM_001159401.1 NP_001152873.1 uridine phosphorylase 1
NM_001159402.1 NP_001152874.1 uridine phosphorylase 1
NM_009477.3 NP_033503.2 uridine phosphorylase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables deoxyuridine phosphorylase activity IDA
IDA: Inferred from direct assay
7744869 MGI
NOT enables thymidine phosphorylase activity IMP
IMP: Inferred from mutant phenotype
15772079 MGI
enables thymidine phosphorylase activity IMP
IMP: Inferred from mutant phenotype
12077348 MGI
enables uridine phosphorylase activity IDA
IDA: Inferred from direct assay
7744869 MGI
enables uridine phosphorylase activity IMP
IMP: Inferred from mutant phenotype
11956089 MGI
Biological Process GO Annotation Evidence References Source
involved in CMP catabolic process IDA
IDA: Inferred from direct assay
14715930 MGI
involved in UMP catabolic process IDA
IDA: Inferred from direct assay
7744869 MGI
involved in UMP salvage IMP
IMP: Inferred from mutant phenotype
11956089 MGI
involved in dCMP catabolic process IDA
IDA: Inferred from direct assay
7744869 MGI
NOT involved in dTMP catabolic process IMP
IMP: Inferred from mutant phenotype
15772079 MGI
involved in dTMP catabolic process IMP
IMP: Inferred from mutant phenotype
12077348 MGI
involved in dUMP catabolic process IDA
IDA: Inferred from direct assay
14154460 MGI
acts upstream of or within pyrimidine nucleotide metabolic process IMP
IMP: Inferred from mutant phenotype
15772079 MGI
involved in uridine catabolic process IDA
IDA: Inferred from direct assay
7744869 MGI
acts upstream of or within uridine metabolic process IMP
IMP: Inferred from mutant phenotype
15772079 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
7744869 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

uridine phosphorylase 1

  • UPase 1

  • urdPase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106406 Benzylacyclouridine 98.02% Phase 4
HY-W008491 TK-112690 Inhibitor 99.91% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15490 UPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17195 Upp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23647 Upp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Upp1 NCBI NCBI:7378