UPP1 - uridine phosphorylase 1 Gene

Also Known as UP; UPP; UPASE; UDRPASE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7378

About UPP1

Cytogenetic location: 7p12.3 Genomic coordinates (GRCh38): 7:48,088,704-48,108,736 (from NCBI)

This gene has 12 transcripts (splice variants), 229 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 27.1), esophagus (RPKM 7.4) and 19 other tissues.

Summary

This gene encodes a uridine Phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016]

UPP1 Products (6)

mRNA Protein Name
NM_001287426.2 NP_001274355.1 uridine phosphorylase 1 isoform a
NM_001287428.2 NP_001274357.1 uridine phosphorylase 1 isoform b
NM_001287429.2 NP_001274358.1 uridine phosphorylase 1 isoform b
NM_001287430.1 NP_001274359.1 uridine phosphorylase 1 isoform b
NM_001362774.2 NP_001349703.1 uridine phosphorylase 1 isoform a
NM_003364.4 NP_003355.1 uridine phosphorylase 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
19291308 GOA
enables uridine phosphorylase activity IDA
IDA: Inferred from direct assay
7488099 GOA
Biological Process GO Annotation Evidence References Source
involved in uridine catabolic process IDA
IDA: Inferred from direct assay
7488099 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPP1 Protein Structure

PNP_UDP_1

PNP_UDP_1: Phosphorylase superfamily (55 - 303)

  • 0
  • 100
  • 200
  • 310 a.a.
Protein Preferred Names Protein Names

uridine phosphorylase 1

  • UPase 1

Recombinant UPP1 Proteins

Cat. No. Product Name Accession Purity
HY-P71416 UPP1 Protein, Human (His) Q86Y75 (M1-A173) ≥ 90%, as determined by reducing SDS-PAGE.

UPP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87137 Uridine Phosphorylase 1 Antibody (YA6830) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106406 Benzylacyclouridine 98.02% Phase 4
HY-W008491 TK-112690 Inhibitor 99.91% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15490 UPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17195 Upp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23647 Upp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UPP1 VGNC VGNC:36688
Felis catus UPP1 VGNC VGNC:66846
Mus musculus UPP1 MGD MGI:1097668
Rattus norvegicus UPP1 RGD RGD:1305566
Macaca mulatta UPP1 VGNC VGNC:78726
Others UPP1 NCBI