Ezr - ezrin Gene

Also Known as p81; Vil2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22350

Summary

Enables disordered domain specific binding activity and protein C-terminus binding activity. Involved in several processes, including intestinal D-glucose absorption; positive regulation of protein localization to plasma membrane; and terminal web assembly. Acts upstream of or within establishment or maintenance of apical/basal cell polarity and receptor internalization. Located in several cellular components, including brush border; microvillus; and uropod. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human EZR (ezrin). [provided by Alliance of Genome Resources, Apr 2022]

Ezr Products (1)

mRNA Protein Name
NM_009510.2 NP_033536.2 ezrin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables disordered domain specific binding IDA
IDA: Inferred from direct assay
18321067 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9472040 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within establishment or maintenance of apical/basal cell polarity IMP
IMP: Inferred from mutant phenotype
15177033 MGI
involved in intestinal D-glucose absorption IGI
IGI: Inferred from genetic interaction
22114352 MGI
NOT involved in microvillus assembly IGI
IGI: Inferred from genetic interaction
22114352 MGI
involved in positive regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
22114352 MGI
involved in positive regulation of protein localization to plasma membrane IGI
IGI: Inferred from genetic interaction
22114352 MGI
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
29720403 MGI
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
29720403 MGI
acts upstream of or within receptor internalization IMP
IMP: Inferred from mutant phenotype
16365167 MGI
involved in regulation of microvillus length IGI
IGI: Inferred from genetic interaction
22114352 MGI
involved in terminal web assembly IGI
IGI: Inferred from genetic interaction
22114352 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
9890997 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
14625387 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
14996907 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
17122142 MGI
located in microvillus IDA
IDA: Inferred from direct assay
9472040 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
21377456 MGI
located in uropod IDA
IDA: Inferred from direct assay
11728336 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ezrin

  • cytovillin

  • villin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04623 EZR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19860 Ezr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26360 Ezr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ezr NCBI NCBI:7430