Wnt3 - wingless-type MMTV integration site family, member 3 Gene

Also Known as Int-4; Wnt-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22415

Summary

Enables protein domain specific binding activity. Involved in positive regulation of Wnt signaling pathway. Acts upstream of or within several processes, including axis specification; embryonic morphogenesis; and generation of neurons. Located in extracellular matrix. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo ectoderm; and genitourinary system. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human Wnt3 (Wnt family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Wnt3 Products (1)

mRNA Protein Name
NM_009521.3 NP_033547.1 proto-oncogene Wnt-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10866835 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
19000841 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Spemann organizer formation at the anterior end of the primitive streak IMP
IMP: Inferred from mutant phenotype
10431240 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IMP
IMP: Inferred from mutant phenotype
10431240 MGI
acts upstream of or within anterior/posterior axis specification IMP
IMP: Inferred from mutant phenotype
18028899 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
10431240 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
18716223 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18403408 MGI
acts upstream of or within dorsal/ventral axis specification IMP
IMP: Inferred from mutant phenotype
12569130 MGI
acts upstream of or within embryonic forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
12569130 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
12569130 MGI
acts upstream of or within gamete generation IGI
IGI: Inferred from genetic interaction
23469192 MGI
acts upstream of gene expression IDA
IDA: Inferred from direct assay
19690384 MGI
acts upstream of or within head morphogenesis IGI
IGI: Inferred from genetic interaction
18403408 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
12569130 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
10431240 MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
18716223 MGI
involved in positive regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
23324743 MGI
acts upstream of or within positive regulation of collateral sprouting in absence of injury IDA
IDA: Inferred from direct assay
18716223 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
19690384 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
8167409 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proto-oncogene Wnt-3

  • proto-oncogene Int-4

  • proto-oncogene protein Wnt-3

  • wingless-related MMTV integration site 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18006 NKP608 Inhibitor 99.88% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129079A TFMB-(S)-2-HG Inhibitor 99.79% Unkown
HY-N6031 Dendrophenol Inhibitor 99.93% Unkown
HY-122832 ABC99 Inhibitor 98.48% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt3 NCBI NCBI:7473