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Xdh - xanthine dehydrogenase Gene

Also Known as XO; Xor; Xox1; Xox-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22436

About Xdh

Chromosome 17: 74,190,890-74,257,191 reverse strand.GRCm39:CM001010.3

This gene has 14 transcripts (splice variants), 208 orthologues, 4 paralogues and is associated with 41 phenotypes. Broad expression in duodenum adult (RPKM 55.7), small intestine adult (RPKM 47.7) and 16 other tissues.

Summary

This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as Xanthine Oxidase, and functions in purine degradation. Additional studies also suggest a role in adipogenesis, and a function as a structural protein in milk fat droplets in the lactating mammary gland. [provided by RefSeq, Jan 2014]

Xdh Products (1)

mRNA	Protein	Name
NM_011723.3	NP_035853.2	xanthine dehydrogenase/oxidase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables hypoxanthine dehydrogenase activity	IDA IDA: Inferred from direct assay	8064675	MGI
enables hypoxanthine dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	30936145	MGI
enables hypoxanthine oxidase activity	IDA IDA: Inferred from direct assay	8064675	MGI
enables hypoxanthine oxidase activity	IMP IMP: Inferred from mutant phenotype	30936145	MGI
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	17597094	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8541302	MGI
enables xanthine dehydrogenase activity	IDA IDA: Inferred from direct assay	1590774	MGI
enables xanthine dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	12502743	MGI
enables xanthine oxidase activity	IDA IDA: Inferred from direct assay	1590774	MGI
enables xanthine oxidase activity	IMP IMP: Inferred from mutant phenotype	12502743	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in AMP catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in GMP catabolic process	IDA IDA: Inferred from direct assay	8226898	MGI
involved in IMP catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in adenosine catabolic process	IDA IDA: Inferred from direct assay	1590774	MGI
involved in adenosine catabolic process	IMP IMP: Inferred from mutant phenotype	12502743	MGI
involved in allantoin metabolic process	IDA IDA: Inferred from direct assay	1590774	MGI
involved in allantoin metabolic process	IMP IMP: Inferred from mutant phenotype	12502743	MGI
involved in amide catabolic process	IDA IDA: Inferred from direct assay	1590774	MGI
involved in amide catabolic process	IMP IMP: Inferred from mutant phenotype	12502743	MGI
involved in dAMP catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in dGMP catabolic process	IDA IDA: Inferred from direct assay	8226898	MGI
involved in deoxyadenosine catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in deoxyguanosine catabolic process	IDA IDA: Inferred from direct assay	8226898	MGI
involved in deoxyinosine catabolic process	IDA IDA: Inferred from direct assay	1590774	MGI
involved in deoxyinosine catabolic process	IMP IMP: Inferred from mutant phenotype	12502743	MGI
involved in guanine catabolic process	IDA IDA: Inferred from direct assay	1590774	MGI
involved in hypoxanthine catabolic process	IDA IDA: Inferred from direct assay	1590774	MGI
involved in hypoxanthine catabolic process	IMP IMP: Inferred from mutant phenotype	30936145	MGI
involved in inosine catabolic process	IDA IDA: Inferred from direct assay	1590774	MGI
involved in inosine catabolic process	IMP IMP: Inferred from mutant phenotype	12502743	MGI
acts upstream of or within iron-sulfur cluster assembly	IDA IDA: Inferred from direct assay	17597094	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	12502743	MGI
acts upstream of or within regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	12502743	MGI
involved in xanthine catabolic process	IDA IDA: Inferred from direct assay	1590774	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cytosol	IDA IDA: Inferred from direct assay	1590774	MGI
is active in cytosol	IMP IMP: Inferred from mutant phenotype	30936145	MGI
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	19800018	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Xdh Protein Structure

PLN02906

0
300
600
900
1200
1335 a.a.

Protein Preferred Names	Protein Names
xanthine dehydrogenase/oxidase	xanthine oxidase xanthine oxidoreductase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W012658	2-Methylacetophenone	Inhibitor	99.60%	Unkown
HY-RS15869	XDH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15870	Xdh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-106300	AA 193	Inhibitor	/	Unkown
HY-RS13573	SORD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15871	Xdh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W012658R	2-Methylacetophenone (Standard)	Inhibitor	/	Unkown
HY-RS18973	Sord Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25462	Sord Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xdh	NCBI	NCBI:7498