Xrcc5 - X-ray repair complementing defective repair in Chinese hamster cells 5 Gene

Also Known as Ku80; Ku86; CTC85; CTCBF

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22596

Summary

Predicted to enable several functions, including nucleic acid binding activity; protein C-terminus binding activity; and ubiquitin protein Ligase binding activity. Predicted to contribute to 5'-deoxyribose-5-phosphate lyase activity and double-stranded telomeric DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hematopoietic stem cell differentiation; and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Orthologous to human XRCC5 (X-ray repair cross complementing 5). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc5 Products (3)

mRNA Protein Name
NM_001357519.1 NP_001344448.1 X-ray repair cross-complementing protein 5 isoform 2
NM_001357520.1 NP_001344449.1 X-ray repair cross-complementing protein 5 isoform 2
NM_009533.2 NP_033559.2 X-ray repair cross-complementing protein 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23685356 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within double-strand break repair IGI
IGI: Inferred from genetic interaction
12531011 MGI
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
12531011 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
17554309 MGI
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17554309 MGI
acts upstream of or within leptotene IMP
IMP: Inferred from mutant phenotype
17010969 MGI
acts upstream of neurogenesis IMP
IMP: Inferred from mutant phenotype
10716994 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
10716994 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12604618 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12604618 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

X-ray repair cross-complementing protein 5

  • ATP-dependent DNA helicase 2 subunit 2

  • ATP-dependent DNA helicase II 80 kDa subunit

  • CTC box-binding factor 85 kDa subunit

  • DNA repair protein XRCC5

  • Ku p80

  • ku autoantigen protein p86 homolog

  • nuclear factor IV

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15900 XRCC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22924 Xrcc5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29438 Xrcc5 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xrcc5 NCBI NCBI:7520