Yes1 - YES proto-oncogene 1, Src family tyrosine kinase Gene

Also Known as Yes; p61-Yes

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22612

Summary

Predicted to enable several functions, including non-membrane spanning protein tyrosine kinase activity; phosphotyrosine residue binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including cellular response to growth factor stimulus; cellular response to retinoic acid; and positive regulation of nitrogen compound metabolic process. Located in actin filament and plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; pancreas; placenta; and vagal nerve trunk. Orthologous to human YES1 (Yes proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Yes1 Products (3)

mRNA Protein Name
NM_001205132.1 NP_001192061.1 tyrosine-protein kinase Yes
NM_001205133.1 NP_001192062.1 tyrosine-protein kinase Yes
NM_009535.3 NP_033561.1 tyrosine-protein kinase Yes

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11546805 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
26979622 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to platelet-derived growth factor stimulus IDA
IDA: Inferred from direct assay
17623777 MGI
acts upstream of or within cellular response to retinoic acid IDA
IDA: Inferred from direct assay
21385842 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IGI
IGI: Inferred from genetic interaction
21829547 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
21385842 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21385842 MGI
acts upstream of or within regulation of D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
11546805 MGI
Cellular Component GO Annotation Evidence References Source
located in actin filament IDA
IDA: Inferred from direct assay
17623777 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17623777 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Yes

  • Yamaguchi sarcoma viral (v-yes) oncogene homolog 1

  • proto-oncogene c-Yes

  • proto-oncogene tyrosine-protein kinase Yes

  • viral oncogene yes homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112096 eCF506 Inhibitor 99.77% Phase 1

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135299 CH6953755 Inhibitor 99.75% Unkown
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-137342 SB1-G-187 Degrader 98.70% Unkown
HY-137343 DB-0646 Degrader 98.0% Unkown
HY-RS15922 YES1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-112096S eCF506-d5 Inhibitor / Unkown
HY-184792 CA/PRAK-IN-1 Inhibitor / Unkown
HY-E70293 N-Acetylgalactosaminyltransferase 12 / Unkown
HY-174505 Human YAP1 mRNA / Unkown
HY-208739 SRC tyrosine kinase IN-1 Inhibitor / Unkown
HY-RS16970 Yes1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23413 Yes1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Yes1 NCBI NCBI:7525