Yy1 - YY1 transcription factor Gene

Also Known as YY-1; NF-E1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22632

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including immune system development; negative regulation of pri-miRNA transcription by RNA polymerase II; and response to UV-C. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including anterior/posterior pattern specification; camera-type eye morphogenesis; and regulation of gene expression. Located in chromatin and nucleus. Part of PcG protein complex; chromatin silencing complex; and transcription regulator complex. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; female reproductive system; and hemolymphoid system gland. Used to study pleuropulmonary blastoma. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Yy1 Products (1)

mRNA Protein Name
NM_009537.4 NP_033563.2 transcriptional repressor protein YY1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12527199 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11861914 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20843790 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17107999 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24137001 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17107999 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23942234 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
23531880 MGI
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
18026119 MGI
acts upstream of or within RNA localization IMP
IMP: Inferred from mutant phenotype
21729784 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
16624538 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
16624538 MGI
acts upstream of or within camera-type eye morphogenesis IGI
IGI: Inferred from genetic interaction
16624538 MGI
involved in chromosome organization IMP
IMP: Inferred from mutant phenotype
18026119 MGI
acts upstream of or within positive effect gene expression IDA
IDA: Inferred from direct assay
23942234 MGI
involved in hemopoiesis IMP
IMP: Inferred from mutant phenotype
23531880 MGI
involved in immunoglobulin heavy chain V-D-J recombination IMP
IMP: Inferred from mutant phenotype
23531880 MGI
involved in negative regulation of miRNA transcription IDA
IDA: Inferred from direct assay
24675724 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9857059 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20843790 MGI
involved in positive regulation of DNA repair IDA
IDA: Inferred from direct assay
23979016 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
24101522 MGI
involved in positive regulation of telomere maintenance in response to DNA damage IMP
IMP: Inferred from mutant phenotype
23979016 MGI
involved in regulation of DNA repair IDA
IDA: Inferred from direct assay
23979016 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11861914 MGI
involved in regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
23979016 MGI
involved in response to UV-C IMP
IMP: Inferred from mutant phenotype
18026119 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
19786570 MGI
involved in telomere maintenance IMP
IMP: Inferred from mutant phenotype
23979016 MGI
Cellular Component GO Annotation Evidence References Source
part of PcG protein complex IDA
IDA: Inferred from direct assay
16624538 MGI
located in chromatin IDA
IDA: Inferred from direct assay
24675724 MGI
part of chromatin silencing complex IDA
IDA: Inferred from direct assay
26658965 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9857059 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
11861914 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional repressor protein YY1

  • UCR-motif DNA-binding protein

  • UCRBP transcription factor

  • Yin Yang 1

  • delta transcription factor

  • yin and yang 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15946 YY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16713 Yy1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184329 PROTAC AURKB Degrader-1 / Unkown
HY-RS15947 YY1AP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23148 Yy1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Yy1 NCBI NCBI:7528