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ITGA11 - integrin subunit alpha 11 Gene

Also Known as HsT18964

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22801

About ITGA11

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,296,532-68,432,163 (from NCBI)

This gene has 7 transcripts (splice variants), 250 orthologues and 17 paralogues. Biased expression in endometrium (RPKM 12.1), urinary bladder (RPKM 2.7) and 13 other tissues.

Summary

This gene encodes an alpha Integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 Integrin in vitro, and appears to bind Collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]

ITGA11 Products (1)

mRNA	Protein	Name
NM_001004439.2	NP_001004439.1	integrin alpha-11 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IMP IMP: Inferred from mutant phenotype	11518510	GOA
enables collagen binding involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	24823363	GOA
enables collagen receptor activity	IMP IMP: Inferred from mutant phenotype	11518510	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	11518510	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	11518510	GOA
involved in collagen-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	11518510	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24823363	GOA
involved in substrate-dependent cell migration	IMP IMP: Inferred from mutant phenotype	11518510	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	11518510	GOA
part of integrin alpha11-beta1 complex	IDA IDA: Inferred from direct assay	24823363	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA11 Protein Structure

VWA

FG-GAP

Integrin_alpha2

0
200
400
600
800
1000
1188 a.a.

Protein Preferred Names	Protein Names
integrin alpha-11

Related Diseases

Diseases	Alias
Brain Oligodendroglioma	Oligodendroglioma Of Brain
Myasthenic Syndrome, Congenital, 19	Congenital Myasthenic Syndrome 19 CMS19 Myasthenic Syndrome, Congenital, Type 19
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Spinal Muscular Atrophy, Type Iv	SMA4 Spinal Muscular Atrophy, Adult Form Spinal Muscular Atrophy 4 Spinal Muscular Atrophy-4 Adult Spinal Muscular Atrophy Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive Proximal Spinal Muscular Atrophy Type 4 Sma Type 4 Sma Type Iv Sma-Iv Sma Iv Spinal Muscular Atrophy Adult Form Spinal Muscular Atrophy Proximal Adult Autosomal Recessive Spinal Muscular Atrophy Type Iv Atrophy, Muscular, Spinal, Type Iv Myelopathic Muscular Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06947	ITGA11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21144	Itga11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27661	Itga11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ITGA11	VGNC	VGNC:42122
Macaca mulatta	ITGA11	VGNC	VGNC:73774
Bos taurus	ITGA11	VGNC	VGNC:30312
Mus musculus	ITGA11	MGD	MGI:2442114
Rattus norvegicus	ITGA11	RGD	RGD:1311711
Felis catus	ITGA11	VGNC	VGNC:67838
Others	ITGA11	NCBI