FKBP2 - FKBP prolyl isomerase 2 Gene

Also Known as FKBP13; PPIase; FKBP-13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2286

About FKBP2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,241,095-64,244,135 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 18 paralogues. Ubiquitous expression in kidney (RPKM 33.5), thyroid (RPKM 33.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

FKBP2 Products (8)

mRNA Protein Name
NM_001135208.2 NP_001128680.1 peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_001370360.1 NP_001357289.1 peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_001370362.1 NP_001357291.1 peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_001370363.1 NP_001357292.1 peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_001370365.1 NP_001357294.1 peptidyl-prolyl cis-trans isomerase FKBP2 isoform 2
NM_001370367.1 NP_001357296.1 peptidyl-prolyl cis-trans isomerase FKBP2 isoform 3
NM_004470.4 NP_004461.2 peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_057092.2 NP_476433.1 peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FKBP2 Protein Structure

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (43 - 134)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP2

  • 13 kDa FK506-binding protein

FKBP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FKBP2 P26885 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
FKBP2 P26885 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
FKBP2 P26885 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
FKBP2 P26885 UBQLN4 Homo sapiens Q9NRR5
Y2H Array
16713569
Intra
FKBP2 P26885 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
25416956
Intra
FKBP2 P26885 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
FKBP2 P26885 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
FKBP2 P26885 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
FKBP2 P26885 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
FKBP2 P26885 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
FKBP2 P26885 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FKBP2 Proteins

Cat. No. Product Name Accession Purity
HY-P70333 FKBP2 Protein, Human (HEK293, His) P26885 (A22-L142) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 2

  • Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss

  • EDSKSCL2

  • Edskmh

  • Ehlers-Danlos Syndrome Kyphoscoliotic Type 2

  • Kyphoscoliotic Ehlers-Danlos Syndrome Due To Fkbp22 Deficiency

  • Ehlers-Danlos Syndrome With Kyphoscoliosis, Myopathy, And Deafness

  • Ehlers-Danlos Syndrome With Kyphoscoliosis, Myopathy, And Hearing Loss

  • Fkbp14-Related Eds

  • Fkbp22-Deficient Eds

  • Kyphoscoliotic Eds Due To Fkbp22 Deficiency

  • Keds-Fkbp14

  • Ehlers-Danlos Syndrome, With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss

  • Ehlers-Danlos Syndrome, Kyphoscoliotic, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04962 FKBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20405 Fkbp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24787 Fkbp1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26914 Fkbp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FKBP2 VGNC VGNC:110506
Mus musculus FKBP2 MGD MGI:95542
Canis familiaris FKBP2 VGNC VGNC:40889
Felis catus FKBP2 VGNC VGNC:101458
Others FKBP2 NCBI