2. Gene
  3. FKBP3 - FKBP prolyl isomerase 3 Gene

FKBP3 - FKBP prolyl isomerase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FKBP-3; FKBP25; PPIase; FKBP-25

Gene ID: 2287 | Gene type: protein coding

About FKBP3

Cytogenetic location: 14q21.2 Genomic coordinates (GRCh38): 14:45,115,599-45,134,481 (from NCBI)

This gene has 4 transcripts (splice variants), 235 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 15.6), prostate (RPKM 14.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, Casein Kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

FKBP3 Products(1)

mRNA Protein Name
NM_002013.4 NP_002004.1 peptidyl-prolyl cis-trans isomerase FKBP3

FKBP3 Protein Structure

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (122 - 221)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP3

25 kDa FK506-binding protein

Recombinant FKBP3 Proteins

Cat. No. Product Name Accession Purity
HY-P70403 FKBP3 Protein, Human (His) Q00688 (M1-D224) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04963 FKBP3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FKBP3 VGNC VGNC:84339
Rattus norvegicus FKBP3 RGD RGD:1304992
Felis catus FKBP3 VGNC VGNC:80972
Bos taurus FKBP3 VGNC VGNC:29022
Canis familiaris FKBP3 VGNC VGNC:50526
Mus musculus FKBP3 MGD MGI:1353460
Others FKBP3 NCBI