CLSTN1 - calsyntenin 1 Gene

Also Known as CST-1; CSTN1; CDHR12; PIK3CD; ALC-ALPHA; XB31alpha; alcalpha1; alcalpha2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22883

About CLSTN1

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,728,926-9,824,526 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 135.7), skin (RPKM 44.9) and 23 other tissues.

Summary

This gene is a member of the calsyntenin family, a subset of the Cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

CLSTN1 Products (3)

mRNA Protein Name
NM_001009566.3 NP_001009566.1 calsyntenin-1 isoform 1 precursor
NM_001302883.1 NP_001289812.1 calsyntenin-1 isoform 3 precursor
NM_014944.4 NP_055759.3 calsyntenin-1 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables X11-like protein binding IPI
IPI: Inferred from physical interaction
12972431 GOA
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
17332754 GOA
enables kinesin binding IPI
IPI: Inferred from physical interaction
17332754 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17332754 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLSTN1 Protein Structure

Cadherin

Cadherin: Cadherin domain (169 - 257)

Laminin_G_3

Laminin_G_3: Concanavalin A-like lectin/glucanases superfamily (363 - 551)

  • 0
  • 200
  • 400
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  • 800
  • 981 a.a.
Protein Preferred Names Protein Names

calsyntenin-1

  • alcadein-alpha

CLSTN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
CLSTN1 O94985 Klc1 Mus musculus Q8CD76
Anti Tag CoIP
17332754
Cross
CLSTN1 O94985 Klc1 Mus musculus Q8CD76
Pull Down
17332754
Intra
CLSTN1 O94985 APBA2 Homo sapiens Q99767
Anti Tag CoIP
17332754
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLSTN1 Proteins

Cat. No. Product Name Accession Purity
HY-P76271 CLSTN1 Protein, Human (HEK293, His) O94985-1 (A29-T859) ≥ 95%, as determined by reducing SDS-PAGE.

CLSTN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82502 CLSTN1 Antibody (YA2247) WB, IHC-P, ICC/IF Human, Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176712 GSNOR-IN-1 Inhibitor / Unkown
HY-RS02840 CLSTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20146 Clstn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26650 Clstn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLSTN1 VGNC VGNC:27466
Rattus norvegicus CLSTN1 RGD RGD:1306458
Mus musculus CLSTN1 MGD MGI:1929895
Felis catus CLSTN1 VGNC VGNC:60979
Macaca mulatta CLSTN1 VGNC VGNC:82127
Others CLSTN1 NCBI