CLSTN1 - calsyntenin 1 Gene

Homo sapiens

Also known as CST-1; CSTN1; CDHR12; PIK3CD; ALC-ALPHA; XB31alpha; alcalpha1; alcalpha2

Gene ID: 22883 | Gene type: protein coding

About CLSTN1

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,728,926-9,824,526 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 135.7), skin (RPKM 44.9) and 23 other tissues.

Summary

This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

CLSTN1 Products(3)

mRNA	Protein	Name
NM_001009566.3	NP_001009566.1	calsyntenin-1 isoform 1 precursor
NM_001302883.1	NP_001289812.1	calsyntenin-1 isoform 3 precursor
NM_014944.4	NP_055759.3	calsyntenin-1 isoform 2 precursor

CLSTN1 Protein Structure

Cadherin

Laminin_G_3

0
200
400
600
800
981 a.a.

Protein Preferred Names

Protein Names

calsyntenin-1

alcadein-alpha

Recombinant CLSTN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76271	CLSTN1 Protein, Human (HEK293, His)	O94985-1 (A29-T859)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02840	CLSTN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLSTN1	VGNC	VGNC:27466
Rattus norvegicus	CLSTN1	RGD	RGD:1306458
Mus musculus	CLSTN1	MGD	MGI:1929895
Felis catus	CLSTN1	VGNC	VGNC:60979
Macaca mulatta	CLSTN1	VGNC	VGNC:82127
Others	CLSTN1	NCBI

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