Cenpe - centromere protein E Gene

Also Known as Kif10; 312kDa; CENP-E; C530022J18

Species: Mus musculus

Gene Type: protein coding

Gene ID: 229841

About Cenpe

Chromosome 3: 134,918,298-134,979,372 forward strand.GRCm39:CM000996.3

This gene has 5 transcripts (splice variants), 147 orthologues, 43 paralogues and is associated with 11 phenotypes. Biased expression in CNS E11.5 (RPKM 11.9), liver E14 (RPKM 8.2) and 9 other tissues.

Summary

Enables kinetochore binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of protein kinase activity; and regulation of mitotic metaphase/anaphase transition. Acts upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Located in kinetochore. Part of outer kinetochore. Is expressed in testis and thymus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Apr 2022]

Cenpe Products (2)

mRNA	Protein	Name
NM_173762.4	NP_776123.3	centromere-associated protein E
NM_173762.4	NP_776123.3	centromere-associated protein E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinetochore binding	IDA IDA: Inferred from direct assay	12925705	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12925705	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	12925705	MGI
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	12925705	MGI
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	12925705	MGI
involved in positive regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	12361599	MGI
involved in positive regulation of chromosome segregation	IMP IMP: Inferred from mutant phenotype	12925705	MGI
involved in positive regulation of mitotic metaphase/anaphase transition	IMP IMP: Inferred from mutant phenotype	12925705	MGI
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	12925705	MGI
involved in regulation of developmental process	IMP IMP: Inferred from mutant phenotype	12361599	MGI
involved in regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	12361599	MGI
acts upstream of or within regulation of protein stability	IMP IMP: Inferred from mutant phenotype	23541922	MGI
acts upstream of or within spindle assembly involved in female meiosis I	IMP IMP: Inferred from mutant phenotype	23541922	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in kinetochore	IDA IDA: Inferred from direct assay	12925705	MGI
part of outer kinetochore	IDA IDA: Inferred from direct assay	19283064	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cenpe Protein Structure

KISc_CENP_E

Smc

SMC_prok_B

0
400
800
1200
1600
2000
2471 a.a.

Protein Preferred Names	Protein Names
centromere-associated protein E	N-7 kinesin centromere autoantigen E centromeric protein E kinesin 10 kinesin superfamily protein 10 motor domain of KIF10

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10299	GSK-923295		99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19530	PF-2771	Inhibitor	99.66%	Unkown
HY-121569	Syntelin	Inhibitor	98.25%	Unkown
HY-RS02476	CENPE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-150265	TNH	Activator	/	Unkown
HY-161897	CENP-E-IN-2	Inhibitor	/	Unkown
HY-161898	CENP-E-IN-3	Inhibitor	/	Unkown
HY-RS02477	Cenpe Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02478	Cenpe Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-110090	UA62784		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cenpe	NCBI	NCBI:1062