2. Gene
  3. Cenpe - centromere protein E Gene

Cenpe - centromere protein E Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Kif10; 312kDa; CENP-E; C530022J18

Gene ID: 229841 | Gene type: protein coding

About Cenpe

Chromosome 3: 134,918,298-134,979,372 forward strand.GRCm39:CM000996.3

This gene has 5 transcripts (splice variants), 147 orthologues, 43 paralogues and is associated with 11 phenotypes. Biased expression in CNS E11.5 (RPKM 11.9), liver E14 (RPKM 8.2) and 9 other tissues.

Summary

Enables kinetochore binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of protein kinase activity; and regulation of mitotic metaphase/anaphase transition. Acts upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Located in kinetochore. Part of outer kinetochore. Is expressed in testis and thymus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Apr 2022]

Cenpe Products(1)

mRNA Protein Name
NM_173762.4 NP_776123.3 centromere-associated protein E

Cenpe Protein Structure

KISc_CENP_E

KISc_CENP_E: cd01374 (5 - 328)

Smc

Smc: cl34174 (333 - 1074)

Smc

Smc: cl34174 (833 - 1619)

SMC_prok_B

SMC_prok_B: cl37069 (1322 - 2039)

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  • 2471 a.a.
Protein Preferred Names Protein Names

centromere-associated protein E

N-7 kinesin

centromere autoantigen E

centromeric protein E

kinesin 10

kinesin superfamily protein 10

motor domain of KIF10

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10299 GSK-923295 99.82% Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19530 PF-2771 Inhibitor 99.76% Unkown
HY-RS02476 CENPE Human Pre-designed siRNA Set A / Unkown
HY-RS02477 Cenpe Mouse Pre-designed siRNA Set A / Unkown
HY-RS02478 Cenpe Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cenpe NCBI NCBI:1062