SV2C - synaptic vesicle glycoprotein 2C Gene

Also Known as SLC22B3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22987

About SV2C

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:75,847,464-76,353,939 (from NCBI)

This gene has 3 transcripts (splice variants), 276 orthologues and 2 paralogues. Biased expression in brain (RPKM 1.2), adrenal (RPKM 0.7) and 8 other tissues.

Summary

Predicted to enable transmembrane transporter activity. Predicted to be involved in chemical synaptic transmission; neurotransmitter transport; and transmembrane transport. Predicted to be located in plasma membrane and synaptic vesicle. Predicted to be active in neuron projection and synaptic vesicle membrane. Predicted to be integral component of synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SV2C Products (2)

mRNA	Protein	Name
NM_001297716.2	NP_001284645.1	synaptic vesicle glycoprotein 2C isoform 2
NM_014979.4	NP_055794.3	synaptic vesicle glycoprotein 2C isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24240280	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SV2C Protein Structure

Sugar_tr

Pentapeptide_4

MFS_1

0
200
400
600
727 a.a.

Protein Preferred Names	Protein Names
synaptic vesicle glycoprotein 2C	solute carrier family 22 member B3

SV2C Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84626	SV2C Antibody (YA4323)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84626A	SV2C Antibody (YA4323)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Foodborne Botulism	Botulism Botulism Poisoning Intoxication With Clostridium Botulinum Toxin Wound Botulism Food Poisoning Due To Clostridium Botulinum Infection Due To Clostridium Botulinum Infant Botulism Intoxication Botulism Botulism, Infantile Clostridium Botulinum Poisoning Botulism Nos
Intestinal Botulism	Intestinal Colonization Botulism Intestinal Toxemia Botulism Intestinal Toxin-Mediated Botulism
Infant Botulism	Infant Intestinal Botulism Infant Intestinal Toxemia Botulism Infant Intestinal Toxin-Mediated Botulism Infantile Botulism Botulism, Infantile
Wound Botulism	Cutaneous Infectious Botulism Cutaneous Toxin-Mediated Botulism Inoculation Botulism Skin Infectious Botulism Skin Toxin-Mediated Botulism
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14056	SV2C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SV2C	VGNC	VGNC:35496
Macaca mulatta	SV2C	VGNC	VGNC:78252
Felis catus	SV2C	VGNC	VGNC:65862
Mus musculus	SV2C	MGD	MGI:1922459
Rattus norvegicus	SV2C	RGD	RGD:619718
Canis familiaris	SV2C	VGNC	VGNC:47005
Others	SV2C	NCBI