Crocc - ciliary rootlet coiled-coil, rootletin Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230872

Summary

Enables actin binding activity; Kinesin binding activity; and structural molecule activity. A structural constituent of Cytoskeleton. Acts upstream of or within ciliary basal body organization; establishment of organelle localization; and tissue homeostasis. Located in several cellular components, including cytoskeleton; photoreceptor inner segment; and subapical part of cell. Is expressed in brain; metanephros; and retina layer. Orthologous to human CROCC (ciliary rootlet coiled-coil, rootletin). [provided by Alliance of Genome Resources, Apr 2022]

Crocc Products (2)

mRNA Protein Name
NM_001145958.1 NP_001139430.1 rootletin isoform 2
NM_172122.2 NP_742120.2 rootletin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
15870283 MGI
enables kinesin binding IPI
IPI: Inferred from physical interaction
16018997 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23746204 MGI
enables structural constituent of cytoskeleton IMP
IMP: Inferred from mutant phenotype
15870283 MGI
enables structural molecule activity IDA
IDA: Inferred from direct assay
12427867 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular homeostasis IMP
IMP: Inferred from mutant phenotype
15870283 MGI
acts upstream of or within ciliary basal body organization IMP
IMP: Inferred from mutant phenotype
15870283 MGI
acts upstream of or within epithelial structure maintenance IMP
IMP: Inferred from mutant phenotype
15870283 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15870283 MGI
acts upstream of or within establishment of organelle localization IMP
IMP: Inferred from mutant phenotype
15870283 MGI
acts upstream of or within photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
15870283 MGI
Cellular Component GO Annotation Evidence References Source
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
29891944 MGI
located in centriole IDA
IDA: Inferred from direct assay
16339073 MGI
located in ciliary rootlet IDA
IDA: Inferred from direct assay
16018997 MGI
located in ciliary rootlet IMP
IMP: Inferred from mutant phenotype
15870283 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
23178122 MGI
located in subapical part of cell IDA
IDA: Inferred from direct assay
29891944 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rootletin

  • ciliary rootlet coiled-coil protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03193 CROCC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22457 Crocc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28980 Crocc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crocc NCBI NCBI:9696