Insig1 - insulin induced gene 1 Gene

Also Known as Insig-1; 1810013C12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231070

Summary

Predicted to enable oxysterol binding activity. Acts upstream of or within several processes, including ear morphogenesis; negative regulation of fat cell differentiation; and negative regulation of lipid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; ganglia; neural retina; telencephalon ventricular layer; and vibrissa. Orthologous to human INSIG1 (Insulin induced gene 1). [provided by Alliance of Genome Resources, Apr 2022]

Insig1 Products (1)

mRNA Protein Name
NM_153526.5 NP_705746.1 insulin-induced gene 1 protein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12242332 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol biosynthetic process IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within cholesterol metabolic process IGI
IGI: Inferred from genetic interaction
16100574 MGI
acts upstream of or within cranial suture morphogenesis IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within middle ear morphogenesis IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
12869692 MGI
acts upstream of or within negative regulation of fatty acid biosynthetic process IGI
IGI: Inferred from genetic interaction
16100574 MGI
acts upstream of or within negative regulation of steroid biosynthetic process IGI
IGI: Inferred from genetic interaction
16100574 MGI
acts upstream of or within response to sterol depletion IDA
IDA: Inferred from direct assay
12242332 MGI
acts upstream of or within roof of mouth development IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within sterol biosynthetic process IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within triglyceride metabolic process IGI
IGI: Inferred from genetic interaction
16100574 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-induced gene 1 protein

  • INSIG-1 membrane protein

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109056 Elsulfavirine Inhibitor 99.90% Unkown

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-109056A Elsulfavirine sodium Inhibitor / Unkown
HY-121012 (rac)-AG-205 / Unkown
HY-N20666 Canola oil / Unkown
HY-RS06837 INSIG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17851 Insig1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24319 Insig1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Insig1 NCBI NCBI:3638