Uba6 - ubiquitin-like modifier activating enzyme 6 Gene

Also Known as E1-L2; Ube1l2; 4930542H01; 5730469D23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231380

Summary

Enables FAT10 activating enzyme activity and ubiquitin activating enzyme activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including dendritic spine development; learning; and limbic system development. Predicted to be active in cytoplasm and nucleus. Is expressed in gonad. Orthologous to human UBA6 (ubiquitin like modifier activating enzyme 6). [provided by Alliance of Genome Resources, Apr 2022]

Uba6 Products (1)

mRNA Protein Name
NM_172712.2 NP_766300.1 ubiquitin-like modifier-activating enzyme 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables FAT10 activating enzyme activity IMP
IMP: Inferred from mutant phenotype
17889673 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17889673 MGI
enables ubiquitin activating enzyme activity IMP
IMP: Inferred from mutant phenotype
23499007 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within amygdala development IMP
IMP: Inferred from mutant phenotype
23499007 MGI
acts upstream of or within dendritic spine development IMP
IMP: Inferred from mutant phenotype
23499007 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
23499007 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
23499007 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
23499007 MGI
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
17889673 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IGI
IGI: Inferred from genetic interaction
23499007 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
17889673 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-like modifier-activating enzyme 6

  • ubiquitin-activating enzyme 6

  • ubiquitin-activating enzyme E1-like 2

  • ubiquitin-activating enzyme E1-like protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153774 UBA6-IN-1 Inhibitor / Unkown
HY-RS15324 UBA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19393 Uba6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25885 Uba6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uba6 NCBI NCBI:55236