Slc6a1 - solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Gene

Also Known as Gabt; Gat1; XT-1; GAT-1; Gabt1; Xtrp1; GABATR; GABATHG; A730043E01

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232333

Summary

Enables gamma-aminobutyric acid transmembrane transporter activity. Involved in gamma-aminobutyric acid import. Located in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including heart; nervous system; respiratory system; sensory organ; and skeleton. Used to study schizophrenia. Orthologous to human SLC6A1 (solute carrier family 6 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a1 Products (1)

mRNA Protein Name
NM_178703.5 NP_848818.1 sodium- and chloride-dependent GABA transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amino acid:sodium symporter activity IDA
IDA: Inferred from direct assay
30270321 MGI
enables gamma-aminobutyric acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
15106822 MGI
enables gamma-aminobutyric acid:sodium:chloride symporter activity IDA
IDA: Inferred from direct assay
8420981 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of associative learning IMP
IMP: Inferred from mutant phenotype
11742587 MGI
involved in gamma-aminobutyric acid import IMP
IMP: Inferred from mutant phenotype
15106822 MGI
acts upstream of memory IMP
IMP: Inferred from mutant phenotype
11742587 MGI
involved in neurotransmitter reuptake IDA
IDA: Inferred from direct assay
12815026 MGI
involved in neurotransmitter reuptake IMP
IMP: Inferred from mutant phenotype
12815026 MGI
acts upstream of synapse organization IMP
IMP: Inferred from mutant phenotype
11742587 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
12815026 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
12815026 MGI
located in axon IDA
IDA: Inferred from direct assay
11742587 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
11742587 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17724084 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium- and chloride-dependent GABA transporter 1

  • gamma-aminobutyric acid (GABA-A) transporter 1

  • solute carrier family 6 member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13296 SLC6A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21939 Slc6a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28456 Slc6a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a1 NCBI NCBI:6529