Nsd3 - nuclear receptor binding SET domain protein 3 Gene

Also Known as WHISTLE; Whsc1l1; 6720429E03; A530023P05

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234135

Summary

This gene encodes a member of the SET domain family of histone lysine N-methyltransferase proteins. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. It acts in opposition to the Histone Demethylase Jmjd1c. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]

Nsd3 Products (4)

mRNA Protein Name
NM_001001735.2 NP_001001735.1 histone-lysine N-methyltransferase NSD3 isoform 1
NM_001081269.2 NP_001074738.1 histone-lysine N-methyltransferase NSD3 isoform 2
NM_001308481.1 NP_001295410.1 histone-lysine N-methyltransferase NSD3 isoform 1
NM_001308482.1 NP_001295411.1 histone-lysine N-methyltransferase NSD3 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histone H3K27 methyltransferase activity IDA
IDA: Inferred from direct assay
16682010 MGI
enables histone H3K4 methyltransferase activity IDA
IDA: Inferred from direct assay
16682010 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16682010 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase NSD3

  • WHSC1-like protein 1

  • nuclear SET domain-containing protein 3

  • wolf-Hirschhorn syndrome candidate 1-like protein 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114208A BI-9321 trihydrochloride Antagonist 99.83% Unkown
HY-114340 LEM-14 98.02% Unkown
HY-155815 MS9715 99.48% Unkown
HY-162308 NSD-IN-3 98.0% Unkown
HY-142095 NSD3-IN-3 Inhibitor 98.0% Unkown
HY-125244 LEM-14-1189 Inhibitor 99.76% Unkown
HY-155816 PROTAC NSD3 degrader-1 99.40% Unkown
HY-114208 BI-9321 Antagonist / Unkown
HY-142093 NSD3-IN-1 Inhibitor / Unkown
HY-142094 NSD3-IN-2 Inhibitor / Unkown
HY-168920 NSD-IN-4 / Unkown
HY-RS09589 NSD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-142048 BI-9466 Antagonist / Unkown
HY-175630 BI-9321-C10-acid Ligand / Unkown
HY-RS17221 Nsd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23674 Nsd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nsd3 NCBI NCBI:54904