2. Epigenetics
  3. Histone Methyltransferase
  4. NSD3-IN-3

NSD3-IN-3 is a potent NSD3 inhibtor with an IC50 value of 1.86 μM. NSD3-IN-3 has anticancer activity and significantly inhibits the growth and proliferation of non-small cell lung cancer cell line H460.

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NSD3-IN-3 Chemical Structure

NSD3-IN-3 Chemical Structure

CAS No. : 445416-12-6

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NSD3-IN-3 Related Antibodies

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Description

NSD3-IN-3 is a potent NSD3 inhibtor with an IC50 value of 1.86 μM. NSD3-IN-3 has anticancer activity and significantly inhibits the growth and proliferation of non-small cell lung cancer cell line H460[1].

IC50 & Target[1]

NSD3

1.86 μM (IC50)

In Vitro

NSD3-IN-3 (compound B2) (0-10 μM; 48 h) completely inhibits H3K36me3 modification in H460 and H1299 cells at 10 μM[1].
NSD3-IN-3 (0-20 μM; 48 h) inhibits cell growth of H460 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSD3-IN-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: Non-small cell lung cancer cell line H460
Concentration: 0, 2.5, 5, 10, and 20 μM
Incubation Time: 48 hours
Result: Inhibited cell growth dose-dependently.
Molecular Weight

331.39

Formula

C15H17N5O2S
CAS No.
SMILES

S=C1NC2=C(N)N=CN=C2N1CCOC3=CC=C(OCC)C=C3
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSD3-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSD3-IN-3445416-12-6Histone MethyltransferaseInhibitorinhibitorinhibit

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