PRAME - PRAME nuclear receptor transcriptional regulator Gene

Also Known as MAPE; OIP4; CT130; OIP-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23532

About PRAME

Cytogenetic location: 22q11.22 Genomic coordinates (GRCh38): 22:22,547,701-22,559,265 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 197 orthologues and 24 paralogues. Restricted expression toward testis (RPKM 47.0).

Summary

This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to Cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

PRAME Products (11)

mRNA Protein Name
NM_001291715.2 NP_001278644.1 melanoma antigen preferentially expressed in tumors isoform a
NM_001291716.2 NP_001278645.1 melanoma antigen preferentially expressed in tumors isoform a
NM_001291717.2 NP_001278646.1 melanoma antigen preferentially expressed in tumors isoform b
NM_001291719.2 NP_001278648.1 melanoma antigen preferentially expressed in tumors isoform b
NM_001318126.2 NP_001305055.1 melanoma antigen preferentially expressed in tumors isoform b
NM_001318127.2 NP_001305056.1 melanoma antigen preferentially expressed in tumors isoform b
NM_006115.5 NP_006106.1 melanoma antigen preferentially expressed in tumors isoform a
NM_206953.3 NP_996836.1 melanoma antigen preferentially expressed in tumors isoform a
NM_206954.3 NP_996837.1 melanoma antigen preferentially expressed in tumors isoform a
NM_206955.3 NP_996838.1 melanoma antigen preferentially expressed in tumors isoform a
NM_206956.3 NP_996839.1 melanoma antigen preferentially expressed in tumors isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear retinoic acid receptor binding IDA
IDA: Inferred from direct assay
16179254 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16179254 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
21822215 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16179254 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
16179254 GOA
involved in negative regulation of cell differentiation IDA
IDA: Inferred from direct assay
16179254 GOA
involved in negative regulation of retinoic acid receptor signaling pathway IDA
IDA: Inferred from direct assay
16179254 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16179254 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
26138980 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
21822215 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul2-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
21822215 GOA
located in chromatin IDA
IDA: Inferred from direct assay
21822215 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
21822215 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

melanoma antigen preferentially expressed in tumors

  • Opa-interacting protein OIP4

PRAME Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
PRAME P78395 elc-1 Caenorhabditis elegans Q9BKS1
Pull Down
23460923
Cross
PRAME P78395 elc-1 Caenorhabditis elegans Q9BKS1
Y2H
23460923
Intra
PRAME P78395 ELOC Homo sapiens Q15369
Anti Bait CoIP
21822215
Intra
PRAME P78395 ELOC Homo sapiens Q15369
Anti Tag CoIP
21822215
Intra
PRAME P78395 ELOC Homo sapiens Q15369
Pull Down
21822215
Intra
PRAME P78395 ELOC Homo sapiens Q15369
Pull Down
23460923
Intra
PRAME P78395 ELOC Homo sapiens Q15369
Anti Tag CoIP
23460923
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRAME Proteins

Cat. No. Product Name Accession Purity
HY-P72258 Melanoma antigen preferentially/PRAME, Human (His) P78395 (M1-N509) ≥ 90%, as determined by reducing SDS-PAGE.

PRAME Antibodies

Cat. No. Product Name Application Reactivity
HY-P81966 PRAME Antibody (YA1711) WB, IHC-P, ICC/IF, IP, FC Human
HY-P81966A PRAME Antibody (YA1711)(PBS only) WB, IHC-P, ICC/IF, IP, FC Human

Related Diseases

Diseases Alias
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Acute Leukemia

  • Stem Cell Leukaemia

  • Stem Cell Leukemia

  • Acute Leukemias

  • Acute Undifferentiated Leukemia

  • Undifferentiated Leukemia

  • Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

  • Blast Cell Leukaemia

  • Blast Leukaemia

  • Blastic Leukaemia

  • Undifferentiated Leukaemia
Blastoma

  • Embryoma
Leukemia, Chronic Myeloid

  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia
Choroid Cancer

  • Choroid Neoplasm

  • Choroidal Tumor

  • Malignant Tumor Of Choroid

  • Malignant Tumor Of The Choroid

  • Neoplasm Of Choroid

  • Choroid Neoplasms

  • Primary Malignant Neoplasm Of Choroid
Malignant Spindle Cell Melanoma

  • Spindle Cell Melanoma

  • Desmoplastic Melanoma

  • Spindle Cell Malignant Melanoma

  • Spitzoid Malignant Melanoma
Spitzoid Melanoma

  • Atypical Spitz Nevus
Synovium Cancer

  • Malignant Tumor Of Synovium

  • Synovial Neoplasm
Hematologic Cancer

  • Hematologic Neoplasm

  • Hematologic Neoplasms

  • Hematologic Malignancies

  • Blood Cancer

  • Hematologic Malignancy

  • Hematological Tumors

  • Hematopoietic And Lymphoid System Tumor

  • Hematopoietic Cancer

  • Hematopoietic Neoplasm

  • Hematopoietic Tumors

  • Malignant Hematopoietic Neoplasm

  • Liquid Tumor

  • Hematopoietic Neoplasms
Myxoid Liposarcoma

  • Myxoid/Round Cell Liposarcoma

  • Liposarcoma, Myxoid

  • Mrcls

  • Myxoliposarcoma

  • MXLIPO

  • Liposarcoma Myxoid

  • Liposarcoma
Ocular Melanoma

  • Intraocular Melanoma

  • Uveal Melanoma

  • Eye Melanoma

  • Melanoma Of Eye

  • Melanoma Of The Uvea

  • Malignant Melanoma Of Eye
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Large Cell Acanthoma
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Sarcoma, Synovial

  • Synovial Sarcoma

  • Synovialosarcoma

  • Synovial Cell Sarcoma

  • Sarcoma Synovial
Melanoma, Uveal

  • Uveal Melanoma

  • Choroidal Melanoma

  • Melanoma Of Uvea

  • Iris Melanoma

  • Malignant Melanoma Of Choroid

  • Malignant Melanoma Of Iris
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11280A PRAME peptide (425-433) acetate Degrader 98.16% Unkown
HY-RS11049 PRAME Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990717 Brenetafusp Inhibitor 99.70% Unkown
HY-P992293 Anti-PRAME Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRAME VGNC VGNC:97566
Mus musculus PRAME MGD MGI:1924882
Rattus norvegicus PRAME RGD RGD:1596887
Canis familiaris PRAME VGNC VGNC:54983