DDAH1 - dimethylarginine dimethylaminohydrolase 1 Gene

Homo sapiens

Also known as DDAH; DDAHI; DDAH-1; HEL-S-16

Gene ID: 23576 | Gene type: protein coding

About DDAH1

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:85,318,485-85,578,200 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and 1 paralogue. Broad expression in kidney (RPKM 34.4), brain (RPKM 28.2) and 21 other tissues.

Summary

This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded Enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]

DDAH1 Products(3)

mRNA	Protein	Name
NM_001134445.2	NP_001127917.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 2
NM_001330655.2	NP_001317584.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 3
NM_012137.4	NP_036269.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 1

DDAH1 Protein Structure

Amidinotransf

0
100
200
285 a.a.

Protein Preferred Names

Protein Names

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

NG, NG-dimethylarginine dimethylaminohydrolase

Recombinant DDAH1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79232	DDAH1 Protein, Human (His)	O94760 (A2-S285)	≥95%

Related Diseases

Diseases

Alias

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16958	PD 404182		98.98%	Unkown
HY-RS03604	DDAH1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DDAH1	MGD	MGI:1916469
Felis catus	DDAH1	VGNC	VGNC:61384
Rattus norvegicus	DDAH1	RGD	RGD:70968
Bos taurus	DDAH1	VGNC	VGNC:27939
Macaca mulatta	DDAH1	VGNC	VGNC:71753
Canis familiaris	DDAH1	VGNC	VGNC:39827

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