OPN3 - opsin 3 Gene

Also Known as ECPN; PPP1R116

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23596

About OPN3

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:241,593,124-241,640,369 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and 9 paralogues. Broad expression in placenta (RPKM 19.5), lung (RPKM 11.0) and 24 other tissues.

Summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]

OPN3 Products (3)

mRNA Protein Name
NM_001381855.1 NP_001368784.1 opsin-3 isoform 2
NM_001381856.1 NP_001368785.1 opsin-3 isoform 3
NM_014322.3 NP_055137.2 opsin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 11-cis retinal binding IDA
IDA: Inferred from direct assay
31097585 GOA
enables all-trans retinal binding IDA
IDA: Inferred from direct assay
31097585 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31097585 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to UV-A IDA
IDA: Inferred from direct assay
31380578 GOA
involved in keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
30168605 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
31730232 GOA
involved in negative regulation of melanin biosynthetic process IMP
IMP: Inferred from mutant phenotype
31097585 GOA
involved in positive regulation of melanin biosynthetic process IMP
IMP: Inferred from mutant phenotype
28842328 GOA
involved in response to blue light IDA
IDA: Inferred from direct assay
30168605 GOA
involved in response to blue light IMP
IMP: Inferred from mutant phenotype
28842328 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
30168605 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
30168605 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OPN3 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (59 - 309)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

opsin-3

  • encephalopsin

OPN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OPN3 Q9H1Y3 MC1R Homo sapiens Q01726
Confocal
31097585
Intra
OPN3 Q9H1Y3 MC1R Homo sapiens Q01726
Anti Tag CoIP
31097585
Intra
OPN3 Q9H1Y3 MC1R Homo sapiens Q01726
Anti Bait CoIP
31097585
Cross: Cross-species interaction Intra: Intraspecies interaction

OPN3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83780 OPN3 Antibody WB, IHC-P, ICC/IF Human, Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09798 OPN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21399 Opn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27918 Opn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OPN3 VGNC VGNC:75400
Rattus norvegicus OPN3 RGD RGD:1594385
Felis catus OPN3 VGNC VGNC:107908
Mus musculus OPN3 MGD MGI:1338022
Canis familiaris OPN3 VGNC VGNC:44130
Others OPN3 NCBI